Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax

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dc.contributor.authorRodrigues, Mauricio Martins [UNIFESP]
dc.contributor.authorDutra, Araripe P.
dc.contributor.authorYoshida, Nobuko [UNIFESP]
dc.contributor.institutionNew York University Department of Medical and Molecular Parasitology
dc.contributor.institutionSuperintendência de Controle de Endemias
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:24:21Z
dc.date.available2015-06-14T13:24:21Z
dc.date.issued1991-06-01
dc.description.abstractThe cellular immune response to the circumsporozoite (CS) protein of plasmodium vivax of individuals from malaria-endemic areas of Brazil was studied. We examined the in vitro proliferative response of the peripheral blood mononuclear cells (PBMC) of 22 individuals when stimulated with a CS recombinant protein (rPvCS-2) and two other synthetic peptides based on the sequenceof the P. vivax CS protein. Seven of the individuals from malaria-endemic area displayed an antigen specific in vitro proliferative responseto the recombinant protein PvCS-2 and one out of 6, proliferative response to the peptide 308-320. In contrast, none of the individuals displayed a proliferative reponse when stimulated with the D/A peptide which represent some of the repeated units present in this CS protein. Our study, therefore, provides evidence for the presence, withinthe major surface antigen of P. vivax sporozoites, of epitopes capble to induce proliferation of human PBMC.en
dc.description.affiliationNew York University Department of Medical and Molecular Parasitology
dc.description.affiliationSuperintendência de Controle de Endemias
dc.description.affiliationEscola Paulista de Medicina Disciplina de Parasitologia
dc.description.affiliationUnifespUNIFESP, EPM, Disciplina de Parasitologia
dc.description.sourceSciELO
dc.format.extent153-158
dc.identifierhttp://dx.doi.org/10.1590/S0074-02761991000200003
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, n. 2, p. 153-158, 1991.
dc.identifier.doi10.1590/S0074-02761991000200003
dc.identifier.fileS0074-02761991000200003.pdf
dc.identifier.issn0074-0276
dc.identifier.scieloS0074-02761991000200003
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/281
dc.identifier.wosWOS:A1991GB98100003
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcircumsporozoite proteinen
dc.subjectsporozoite immunityen
dc.subjectmalariaen
dc.subjectT cell epitopesen
dc.titleCellular immune response of humans to the circumsporozoite protein of Plasmodium vivaxen
dc.typeinfo:eu-repo/semantics/article
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