Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado

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dc.citation.issue6
dc.citation.volume83
dc.contributor.authorWandalsen, Gustavo F. [UNIFESP]
dc.contributor.authorMiranda, Carolina [UNIFESP]
dc.contributor.authorEnsina, Luis Felipe [UNIFESP]
dc.contributor.authorSano, Flavio
dc.contributor.authorAmazonas, Roberto Bleul
dc.contributor.authorda Silva, Joyce Macedo
dc.contributor.authorSole, Dirceu [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-09-01T13:21:25Z
dc.date.available2020-09-01T13:21:25Z
dc.date.issued2017
dc.description.abstractIntroduction: A combination of antihistamines and oral corticosteroids is often used to treat acute symptoms of allergic rhinitis. Objective: To evaluate safety and efficacy of desloratadine plus prednisolone in the treatment of acute symptoms of children (2-12 years) with allergic rhinitis, and to compare it to dexchlorpheniramine plus betamethasone. Methods: Children with moderate/severe persistent allergic rhinitis and symptomatic (nasal symptoms score [0-12] >= 6) were allocated in a double-blind, randomized fashion to receive dexchlorpheniramine plus betamethasone (n = 105; three daily doses) or desloratadine plus prednisolone (n = 105; single dose followed by two of placebo) for 7 days. At the beginning and end of the evaluation, the following were obtained: nasal symptoms score, extra nasal symptoms score, peak nasal inspiratory flow, blood biochemistry, and electrocardiogram. Ninety-six children of the dexchlorpheniramine plus betamethasone group and 98 of the desloratadine plus prednisolone group completed the protocol. Results: The two groups were similar regarding initial and final nasal symptoms scores, extra nasal symptoms scores and peak nasal inspiratory flow. A drop of 76.4% and 79.1% for nasal symptoms score, 86.0% and 79.2% for extra nasal symptoms score, as well as an increase of 25.2% and 24.3% for peak nasal inspiratory flow occurred for those treated with desloratadine plus prednisolone and dexchlorpheniramine plus betamethasone, respectively. There were no significant changes in blood chemistry. Sinus tachycardia was the most frequent electrocardiogram change, but with no clinical significance. Drowsiness was reported significantly more often among those of dexchlorpheniramine plus betamethasone group (17.14% x 8.57%, respectively). Conclusion: The desloratadine plus prednisolone combination was able to effectively control acute symptoms of rhinitis in children, improving symptoms and nasal function. Compared to the dexchlorpheniramine plus betamethasone combination, it showed similar clinical action, but with a lower incidence of adverse events and higher dosing convenience. (C) 2016 Published by Elsevier Editora Ltda. on behalf of Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, EPM, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, EPM, Dept Ginecol, Sao Paulo, SP, Brazil
dc.description.affiliationFundacao Apoio Escola Paulista Med FAP, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Santo Amaro Unisa, Clin Med, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Nipo Brasileiro, Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Campinas Unicamp, Campinas, SP, Brazil
dc.description.affiliationFundacao Getulio Vargas, Mkt, Rio De Janeiro, RJ, Brazil
dc.description.affiliationGrp NC Farma, Sao Paulo, SP, Brazil
dc.description.affiliationGrp NC Farma, Pesquisa Clin & Farmacovigilancia, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, EPM, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, EPM, Dept Ginecol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFundacao Apoio Escola Paulista Med FAP, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFunding authority for Studies and Projects (FINEP) - Innovation and Research, Brazil
dc.description.sponsorshipEMS/AS - Sao Paulo, Brazil
dc.description.sponsorshipIDEMS/AS - Sao Paulo, Brazil: 01.12.0094.00
dc.description.sponsorshipIDEMS/AS - Sao Paulo, Brazil: FINEP-1375/10
dc.format.extent633-639
dc.identifierhttp://dx.doi.org/10.1016/j.bjorl.2016.08.009
dc.identifier.citationBrazilian Journal Of Otorhinolaryngology. Sao Paulo, v. 83, n. 6, p. 633-639, 2017.
dc.identifier.doi10.1016/j.bjorl.2016.08.009
dc.identifier.fileS1808-86942017000600633-en.pdf
dc.identifier.fileS1808-86942017000600633-pt.pdf
dc.identifier.issn1808-8694
dc.identifier.scieloS1808-86942017000600633
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58242
dc.identifier.wosWOS:000417392200005
dc.language.isoeng
dc.language.isopor
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.relation.ispartofBrazilian Journal Of Otorhinolaryngology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAllergic rhinitisen
dc.subjectDesloratadineen
dc.subjectDexchlorpheniramineen
dc.subjectPrednisoloneen
dc.subjectBetamethasoneen
dc.subjectRinite alérgicapt
dc.subjectDesloratadinapt
dc.subjectDexclorfeniraminapt
dc.subjectPrednisolonapt
dc.subjectBetametasonapt
dc.titleAssociação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controladopt
dc.title.alternativeAssociation between desloratadine and prednisolone in the treatment of children with acute symptoms of allergic rhinitis: a double-blind, randomized and controlled clinical trialen
dc.typeinfo:eu-repo/semantics/article
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