The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part I

Página do item simplificado
dc.contributor.authorSchmidt, Thomas J.
dc.contributor.authorKhalid, S. A.
dc.contributor.authorRomanha, Álvaro José
dc.contributor.authorAlves, Tânia Maria de Almeida
dc.contributor.authorBiavatti, Maique Weber
dc.contributor.authorBrun, Reto
dc.contributor.authorCosta, Fernando Batista da
dc.contributor.authorCastro, Solange Lisboa de
dc.contributor.authorFerreira, Vitor Francisco
dc.contributor.authorLacerda, Marcus Vinícius Guimarães de
dc.contributor.authorLago, Joao Henrique Ghilardi [UNIFESP]
dc.contributor.authorLeon, Leonor Laura Pinto
dc.contributor.authorLopes, Norberto Peporine
dc.contributor.authorAmorim, Rodrigo César das Neves
dc.contributor.authorNiehues, Michael
dc.contributor.authorOgungbe, Ifedayo Victor
dc.contributor.authorPohlit, Adrian Martin
dc.contributor.authorScotti, Marcus Tullius
dc.contributor.authorSetzer, William Nathan
dc.contributor.authorSoeiro, Maria de Nazaré Correia
dc.contributor.authorSteindel, Mário
dc.contributor.authorTempone, Andre Gustavo [UNIFESP]
dc.contributor.institutionUniv Munster
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionFiocruz MS
dc.contributor.institutionUniv Basel
dc.contributor.institutionSwiss Trop & Publ Hlth Inst STPH
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFundacao Oswaldo Cruz
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionFundacao Med Trop Heitor Vieira Dourado
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Nacl de Pesquisas da Amazonia
dc.contributor.institutionUniv Alabama
dc.contributor.institutionUniv Fed Paraiba
dc.contributor.institutionAdolfo Lutz Inst
dc.date.accessioned2018-06-15T17:05:13Z
dc.date.available2018-06-15T17:05:13Z
dc.date.issued2012-05-01
dc.description.abstractInfections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen Neglected Tropical Diseases (NTDs) defined as such by WHO due to the neglect of financial investment into research and development of new drugs by a large part of pharmaceutical industry and neglect of public awareness in high income countries. Another major tropical protozoan disease is malaria (caused by various Plasmodium species), which -although not mentioned currently by the WHO as a neglected disease- still represents a major problem, especially to people living under poor circumstances in tropical countries. Malaria causes by far the highest number of deaths of all protozoan infections and is often (as in this review) included in the NTDs.The mentioned diseases threaten many millions of lives world-wide and they are mostly associated with poor socioeconomic and hygienic environment. Existing therapies suffer from various shortcomings, namely, a high degree of toxicity and unwanted effects, lack of availability and/or problematic application under the life conditions of affected populations. Development of new, safe and affordable drugs is therefore an urgent need.Nature has provided an innumerable number of drugs for the treatment of many serious diseases. Among the natural sources for new bioactive chemicals, plants are still predominant. Their secondary metabolism yields an immeasurable wealth of chemical structures which has been and will continue to be a source of new drugs, directly in their native form and after optimization by synthetic medicinal chemistry. The current review, published in two parts, attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.en
dc.description.affiliationUniv Munster, IPBP, D-48149 Munster, Germany
dc.description.affiliationUniv Fed Santa Catarina, CCB, Dept Microbiol Immunol & Parasitol MIP, Florianopolis, SC, Brazil
dc.description.affiliationFiocruz MS, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Dept Farm, Florianopolis, SC, Brazil
dc.description.affiliationUniv Basel, CH-4002 Basel, Switzerland
dc.description.affiliationSwiss Trop & Publ Hlth Inst STPH, CH-4002 Basel, Switzerland
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto FCFRP USP, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Lab Biol Celular, Inst Oswaldo Cruz, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Fluminense, Inst Quim, Dept Quim Organ, BR-24020150 Niteroi, RJ, Brazil
dc.description.affiliationFundacao Med Trop Heitor Vieira Dourado, BR-69040000 Manaus, Amazonas, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Lab Bioquim Tripanosomatideos, Inst Oswaldo Cruz, BR-21040900 Rio De Janeiro, RJ, Brazil
dc.description.affiliationInst Nacl de Pesquisas da Amazonia, BR-69060001 Manaus, Amazonas, Brazil
dc.description.affiliationUniv Alabama, Dept Chem, Huntsville, AL 35899 USA
dc.description.affiliationUniv Fed Paraiba, Dept Enghenaria & Meio Ambiente, Ctr Ciencias Aplicadas & Educ, Rio Tinto, Paraiba, Brazil
dc.description.affiliationAdolfo Lutz Inst, Dept Parasitol, BR-01246902 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipGerman Ministry of Science and Education (BMBF)
dc.format.extent2128-2175
dc.identifierhttps://dx.doi.org/10.2174/092986712800229023
dc.identifier.citationCurrent Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 19, n. 14, p. 2128-2175, 2012.
dc.identifier.doi10.2174/092986712800229023
dc.identifier.issn0929-8673
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/43449
dc.identifier.wosWOS:000303381800005
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectNeglected tropical diseasesen
dc.subjectTrypanosomaen
dc.subjectLeishmaniaen
dc.subjectPlasmodiumen
dc.subjectNatural producten
dc.subjectMonoterpeneen
dc.subjectSesquiterpeneen
dc.subjectDiterpeneen
dc.subjectTriterpeneen
dc.titleThe Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part Ien
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
ICAQF - Outras produções