Clinical value of anthropometric estimates of leg lean volume in nutritionally depleted and non-depleted patients with chronic obstructive pulmonary disease

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dc.contributor.authorVillaca, Debora Strose [UNIFESP]
dc.contributor.authorLerario, Maria Cristina [UNIFESP]
dc.contributor.authordal Corso, Simone [UNIFESP]
dc.contributor.authorNapolis, Lara [UNIFESP]
dc.contributor.authorPereira de Albuquerque, Andre Luiz [UNIFESP]
dc.contributor.authorLazaretti-Castro, Marize [UNIFESP]
dc.contributor.authorSachs, Anita [UNIFESP]
dc.contributor.authorNery, Luiz Eduardo [UNIFESP]
dc.contributor.authorNeder, Jose Alberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:36Z
dc.date.available2016-01-24T13:51:36Z
dc.date.issued2008-08-01
dc.description.abstractThis study aimed to investigate the clinical usefulness of an anthropometrically based method for estimating leg lean volume (LLV) in patients with chronic obstructive pulmonary disease (COPD) who presented or not with nutritional depletion. We prospectively evaluated a group of forty-eight patients (thirty-eight males) with moderate to severe COPD (Global Initiative for Chronic Obstructive Lung disease stages II-IV) who underwent a 6 min walking test and knee isokinetic dynamometry. Leg lean mass (muscle mass plus bone) was determined by dual-energy X-ray absorptiometry (DEXA) with derivation of its respective volume: these values were compared with those obtained by the truncated cones method first described by Jones and Pearson in 1969. As expected, depleted patients (n 19) had reduced exercise capacity and impaired muscle performance as compared to non-depleted subjects (P<0.01). the mean bias of the LLV differences between anthropometry and DEXA were 0.40 litre (95 % CI - 0.59, 1.39) and 0.50 litre (95% CI - 1.08, 2.08) for depleted and non-depleted patients, respectively. Anthropometrically and DEXA-based estimates correlated similarly with muscle functional attributes. A ROC curve analysis revealed that leg height-corrected LLV values had acceptable sensitivity and specificity to identify depleted patients (area under the curve 0.93 (range 0.86-1.00); P<0.001). Moreover, patients with LLV <= 9.2 litres/m (the best cut-off value according to the ROC curve) had significantly lower exercise capacity and muscle performance than their counterparts (P<0.05). in conclusion. an anthropometrically based method of estimating LLV (Jones and Pearson method) was shown to present with clinically acceptable accuracy and external validity in depleted and non-depleted patients with stable COPD.en
dc.description.affiliationUNIFESP EPM, Paulista Sch Med, Pulm Funct & Clin Exercise Physiol Unit, Div Resp Dis,Dept Med, BR-04020050 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Endocrinol, Dept Med, BR-04030001 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Nutr, Dept Prevent Med, BR-04038034 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Paulista Sch Med, Pulm Funct & Clin Exercise Physiol Unit, Div Resp Dis,Dept Med, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Endocrinol, Dept Med, BR-04030001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nutr, Dept Prevent Med, BR-04038034 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent380-386
dc.identifierhttp://dx.doi.org/10.1017/S0007114507886399
dc.identifier.citationBritish Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 100, n. 2, p. 380-386, 2008.
dc.identifier.doi10.1017/S0007114507886399
dc.identifier.issn0007-1145
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30829
dc.identifier.wosWOS:000257952000020
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofBritish Journal of Nutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectanthropometryen
dc.subjectDEXAen
dc.subjectchronic obstructive pulmonary diseaseen
dc.subjectbody compositionen
dc.titleClinical value of anthropometric estimates of leg lean volume in nutritionally depleted and non-depleted patients with chronic obstructive pulmonary diseaseen
dc.typeinfo:eu-repo/semantics/article
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