Fetoscopic single-layer repair of open spina bifida using a cellulose patch: preliminary clinical experience

Página do item simplificado
dc.contributor.authorPedreira, Denise A. L.
dc.contributor.authorZanon, Nelci [UNIFESP]
dc.contributor.authorSa, Renato A. M. de
dc.contributor.authorAcacio, Gregorio L.
dc.contributor.authorOgeda, Edilson
dc.contributor.authorBelem, Teresa M. L. O. U.
dc.contributor.authorChmait, Ramen H.
dc.contributor.authorKontopoulos, Eftichia
dc.contributor.authorQuintero, Ruben A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSamaritano Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionUniv Taubate
dc.contributor.institutionUniv So Calif
dc.contributor.institutionJackson Mem Hosp
dc.date.accessioned2016-01-24T14:38:10Z
dc.date.available2016-01-24T14:38:10Z
dc.date.issued2014-11-01
dc.description.abstractObjective: To report our preliminary clinical experience in the antenatal correction of open spina bifida (OSB) using a fetoscopic approach and a simplified closure technique.Methods: Four fetuses with lumbar-sacral defects were operated in utero from 25 to 27 weeks. Surgeries were performed percutaneously under general anesthesia using three trocars and partial carbon dioxide insufflation. After dissection of the neural placode, the surrounding skin was closed over a cellulose patch using a single continuous stitch.Results: Surgical closure was successful in three of the four cases. All successful cases showed improvement of the hindbrain herniation and no neonatal neurosurgical repair was required in two cases. Delivery occurred between 31 and 33 weeks, and no fetal or neonatal deaths occurred. Ventriculoperitoneal shunting was not needed in two out of the 3 successful cases.Conclusions: Our preliminary experience suggests that definitive fetoscopic repair of OSB is feasible using our innovative surgical technique. A phase I trial for the fetoscopic correction of OSB with this technique is currently being conducted.en
dc.description.affiliationUniv São Paulo, Dept Pathol, BR-04020040 São Paulo, Brazil
dc.description.affiliationSamaritano Hosp, Fetal & Perinatal Med Ctr, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurosurg, São Paulo, Brazil
dc.description.affiliationUniv Fed Fluminense, Dept Obstet, Niteroi, RJ, Brazil
dc.description.affiliationUniv Taubate, Dept Obstet, Taubate, Brazil
dc.description.affiliationUniv So Calif, Dept Obstet & Gynecol, Los Angeles, CA 90089 USA
dc.description.affiliationJackson Mem Hosp, Jackson Fetal Therapy Inst, Miami, FL 33136 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurosurg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1613-1619
dc.identifierhttp://dx.doi.org/10.3109/14767058.2013.871701
dc.identifier.citationJournal of Maternal-fetal & Neonatal Medicine. London: Informa Healthcare, v. 27, n. 16, p. 1613-1619, 2014.
dc.identifier.doi10.3109/14767058.2013.871701
dc.identifier.issn1476-7058
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38440
dc.identifier.wosWOS:000343031000001
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofJournal of Maternal-fetal & Neonatal Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectCelluloseen
dc.subjectfetal therapyen
dc.subjectfetoscopyen
dc.subjectmeningomyeloceleen
dc.subjectmyelomeningoceleen
dc.subjectspina bifidaen
dc.titleFetoscopic single-layer repair of open spina bifida using a cellulose patch: preliminary clinical experienceen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral