Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease

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dc.contributor.authorSilva, Patricia Natalia Oliveira da [UNIFESP]
dc.contributor.authorGigek, Carolina Oliveira [UNIFESP]
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorBertolucci, Paulo Henrique Ferreira [UNIFESP]
dc.contributor.authorLabio, Roger Willian de
dc.contributor.authorPayão, Spencer Luiz Marques [UNIFESP]
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFAMEMA
dc.date.accessioned2018-06-15T17:53:01Z
dc.date.available2018-06-15T17:53:01Z
dc.date.issued2008-01-01
dc.description.abstractLongevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease ( AD). Methylation Specifc PCR assay (MSP) was used. There were no significant differences in methylation frequencies of SIRT3, SMARCA5 and CDH1 among young, elderly and AD groups (p > 0.05), showing no association with aging or AD. On the other hand, HTERT methylation frequency was associated with the aging process, in that AD patients differed from elderly controls (p = 0.0086), probably due to telomere and immune dysfunctions involved in AD pathogenesis.en
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Genet, Dept Morfol,Genet Div, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Neurol, Dept Clin Neurol, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationFAMEMA, Hemocentro, Marilia, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Genet, Dept Morfol,Genet Div, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Neurol, Dept Clin Neurol, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent173-176
dc.identifierhttp://dx.doi.org/10.3233/JAD-2008-13207
dc.identifier.citationJournal Of Alzheimers Disease. Amsterdam: Ios Press, v. 13, n. 2, p. 173-176, 2008.
dc.identifier.doi10.3233/JAD-2008-13207
dc.identifier.issn1387-2877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44173
dc.identifier.wosWOS:000254303500007
dc.language.isoeng
dc.publisherIos Press
dc.relation.ispartofJournal Of Alzheimers Disease
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.iospress.nl/service/authors/author-copyright-agreement/
dc.subjectagingen
dc.subjectAlzheimer's diseaseen
dc.subjectCDH1en
dc.subjectDNA methylationen
dc.subjectepigeneticsen
dc.subjectHTERTen
dc.subjectSIRT3en
dc.subjectSMARCA5en
dc.titlePromoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's diseaseen
dc.typeinfo:eu-repo/semantics/article
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