Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88

dc.citation.issue11]
dc.citation.volume19]
dc.contributor.authorCastoldi, Angela
dc.contributor.authorAndrade-Oliveira, Vinicius
dc.contributor.authorAguiar, Cristhiane Favero
dc.contributor.authorAmano, Mariane Tami
dc.contributor.authorLee, Jennifer
dc.contributor.authorMiyagi, Marcelli Terumi
dc.contributor.authorLatancia, Marcela Teatin
dc.contributor.authorBraga, Tarcio Teodoro
dc.contributor.authorda Silva, Marina Burgos
dc.contributor.authorIgnacio, Aline
dc.contributor.authorCarola Correia Lima, Joanna Darck
dc.contributor.authorLoures, Flavio V.
dc.contributor.authorAlbuquerque, Jose Antonio T.
dc.contributor.authorMacedo, Marina Barguil
dc.contributor.authorAlmeida, Rafael Ribeiro
dc.contributor.authorGaiarsa, Jonas W.
dc.contributor.authorLuevano-Martinez, Luis A.
dc.contributor.authorBelchior, Thiago
dc.contributor.authorHiyane, Meire Ioshie
dc.contributor.authorBrown, Gordon D.
dc.contributor.authorMori, Marcelo A.
dc.contributor.authorHoffmann, Christian
dc.contributor.authorSeelaender, Marilia
dc.contributor.authorFestuccia, Willian T.
dc.contributor.authorMoraes-Vieira, Pedro Manoel
dc.contributor.authorSaraiva Camara, Niels Olsen [UNIFESP]
dc.coverageCambridge
dc.date.accessioned2020-06-26T16:30:36Z
dc.date.available2020-06-26T16:30:36Z
dc.date.issued2017
dc.description.abstractThe underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)fed mice resulted in increased weight gain, impaired glucose homeostasis, elevated Dectin-1 expression in adipose tissue (AT), and proinflammatory CD11c+ AT macrophages (ATMs). Dectin-1 KO mice were protected from diet-induced obesity (DIO) and IR and had reduced CD11c+ AT macrophages. Dectin-1 antagonist improved glucose homeostasis and decreased CD11c+ AT macrophages in chow-and HFD-fed MyD88 KO mice. Dectin-1 agonist worsened glucose homeostasis in MyD88 KO mice. Dectin-1 expression is increased in AT from obese individuals. Together, our data indicate that Dectin-1 regulates AT inflammation by promoting CD11c+ AT macrophages in the absence of MyD88 and identify a role for Dectin-1 in chronic inflammatory states, such as obesity. This suggests that Dectin-1 may have ther-apeutic implications as a biomarker for metabolic dysregulation in humans.en
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationHosp Sirio Libanes, Inst Sirio Libanes Ensino & Pesquisa, BR-01308060 Sao Paulo, SP, Brazil
dc.description.affiliationBeth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA
dc.description.affiliationHarvard Med Sch, Boston, MA 02215 USA
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Cellular Biol, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationInst Butantan, Lab Especial Inovacao & Desenvolvimento Ind, BR-05503900 Sao Paulo, SP, Brazil
dc.description.affiliationTau GC Bioinformat, Rua Apiacas 886, BR-05017020 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Bioquim, BR-13565905 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Aberdeen, Inst Med Sci, MRC Ctr Med Mycol, Aberdeen Fungal Grp,Sch Med Med Sci & Nutr, Aberdeen AB24 3FX, Scotland
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Food Res Ctr FoRC, BR-05508080 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Genet Evolut & Bioagents, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Nephrol Div, Lab Clin & Expt Immunol, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Lab Renal Physiol LIM 16, Dept Med, BR-05403000 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Nephrol Div, Lab Clin & Expt Immunol, BR-04023900 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipNIH/NIDDK
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipMRC Centre for Medical Mycology
dc.description.sponsorshipIDFAPESP: 11/15682-4
dc.description.sponsorshipIDFAPESP: 12/02270-2
dc.description.sponsorshipIDFAPESP: 15/18121-4
dc.description.sponsorshipIDCNPq: 465656/2014-5
dc.description.sponsorshipIDNIH/NIDDK: R01DK106210
dc.description.sponsorshipIDWellcome Trust: 102705
dc.description.sponsorshipIDMRC Centre for Medical Mycology: MR/N006364/1
dc.format.extent2272-2288
dc.identifierhttp://dx.doi.org/10.1016/j.celrep.2017.05.059]
dc.identifier.citationCell Reports. Cambridge, v. 19, n. 11, p. 2272-2288, 2017.
dc.identifier.doi10.1016/j.celrep.2017.05.059
dc.identifier.fileWOS000403207700010.pdf
dc.identifier.issn2211-1247
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53659
dc.identifier.wosWOS:000403207700010
dc.language.isoeng
dc.publisherCell Press
dc.relation.ispartofCell Reports
dc.rightsACESSO ABERTO
dc.titleDectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88en
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