Molecular phylogeny and phenotypic variability of clinical and environmental strains of Aspergillus flavus

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dc.contributor.authorGoncalves, Sarah S. [UNIFESP]
dc.contributor.authorCano, Josep F.
dc.contributor.authorStchigel, Alberto M.
dc.contributor.authorMelo, Analy S. [UNIFESP]
dc.contributor.authorGodoy-Martinez, Patricio C.
dc.contributor.authorCorrea, Benedito
dc.contributor.authorGuarro, Josep
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Rovira & Virgili
dc.contributor.institutionUniv Austral Chile
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:27:58Z
dc.date.available2016-01-24T14:27:58Z
dc.date.issued2012-11-01
dc.description.abstractAspergillus flavus is the second most common cause of aspergillosis infection in immunocompromised patients and is responsible for the production of aflatoxins. Little is known about the population structure of A. flavus, although recent molecular and phenotypic data seem to demonstrate that different genetic lineages exist within this species. the aim of this study was to carry out a morphological, physiological, and molecular analysis of a set of clinical and environmental isolates to determine whether this variability is due to species divergence or intraspecific diversity, and to assess whether the clinical isolates form a separate group. the amdS and omtA genes were more phylogenetically informative than the other tested genes and their combined analysis inferred three main clades, with no clear distinction between clinical and environmental isolates. No important morphological and physiological differences were found between the members of the different clades, with the exception of the assimilation of D-glucosamine, which differentiates the members of the clade II from the others. (C) 2012 the British Mycological Society. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUniv Rovira & Virgili, IISPV, Sch Med, Mycol Unit, E-43201 Reus, Spain
dc.description.affiliationUniv Austral Chile, Inst Clin Microbiol, Valdivia, Chile
dc.description.affiliationUniv São Paulo, Biomed Inst 2, Dept Microbiol, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSpanish 'Ministerio de Educacion y Ciencia'
dc.description.sponsorshipFEDER
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDSpanish 'Ministerio de Educacion y Ciencia': CGL 2009-08698/BOS
dc.description.sponsorshipIDCAPES: SWE 4150-08-2
dc.description.sponsorshipIDCNPq: GM/GD 142051/2007-1
dc.format.extent1146-1155
dc.identifierhttp://dx.doi.org/10.1016/j.funbio.2012.08.006
dc.identifier.citationFungal Biology. Oxford: Elsevier B.V., v. 116, n. 11, p. 1146-1155, 2012.
dc.identifier.doi10.1016/j.funbio.2012.08.006
dc.identifier.issn1878-6146
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35469
dc.identifier.wosWOS:000312414300003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFungal Biology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAcetamidase geneen
dc.subjectAflatoxinsen
dc.subjectAspergillus flavusen
dc.subjectO-methyltransferase geneen
dc.subjectPhylogenyen
dc.subjectTaxonomyen
dc.titleMolecular phylogeny and phenotypic variability of clinical and environmental strains of Aspergillus flavusen
dc.typeinfo:eu-repo/semantics/article
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