Age-related changes during a paradigm of chronic sleep restriction

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dc.contributor.authorSouza, Luciane de [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorSmaili, Soraya Soubhi [UNIFESP]
dc.contributor.authorLopes, Guiomar S. [UNIFESP]
dc.contributor.authorHo, Priscila S. [UNIFESP]
dc.contributor.authorPapale, Ligia A. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:48Z
dc.date.available2016-01-24T14:05:48Z
dc.date.issued2010-12-10
dc.description.abstractFragmented and restricted sleep is a common problem for the human elderly. There is evidence that aging impairs sleep in animals as well. After sleep deprivation, older animals have less sleep rebound. Despite increasing complaints of reduced time for sleep in contemporary society, few studies have examined chronic sleep restriction protocols in animals. Therefore, the aim of the present study was to evaluate the effects of chronic sleep restriction on the sleep patterns of aged rats. Using the single platform method, 22-month-old male rats were submitted to 18 h of sleep restriction followed by 6 h of total sleep opportunity. the sleep-wake cycles of these rats were recorded for 6 h/day throughout the 12-day procedure. the results showed that total sleep time and NREM sleep were reduced during the 12-day sleep restriction period. However, rebound REM sleep was only significant on day 6. A negative rebound was also seen, particularly during the last days of the chronic sleep restriction period. Furthermore, sleep latency and mean wake bout length progressively increased during the protocol. These findings indicate that older rats have an inability to restore their sleep patterns during extended sleep deprivation. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 08/50424-3
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.format.extent201-205
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2010.05.025
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 214, n. 2, p. 201-205, 2010.
dc.identifier.doi10.1016/j.bbr.2010.05.025
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33166
dc.identifier.wosWOS:000281318700007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleep restrictionen
dc.subjectSleepen
dc.subjectAgingen
dc.subjectRebounden
dc.subjectEEGen
dc.subjectAged ratsen
dc.titleAge-related changes during a paradigm of chronic sleep restrictionen
dc.typeinfo:eu-repo/semantics/article
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