Persistence or Clearance of Human Papillomavirus Infections in Women in Ouro Preto, Brazil

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dc.contributor.authorMiranda, Priscila Mayrink de
dc.contributor.authorSilva, Nayara Nascimento Toledo
dc.contributor.authorPitol, Bruna Caroline Vieira
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.authorLima-Filho, Jose Luis
dc.contributor.authorCarvalho, Rodrigo Franco de
dc.contributor.authorStocco, Rita de Cassia
dc.contributor.authorBeçak, Willy
dc.contributor.authorLima, Angelica Alves
dc.contributor.institutionInst Butantan
dc.contributor.institutionUniv Ouro Preto UFOP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Fed Integracao Latinoamer UNILA
dc.date.accessioned2016-01-24T14:30:53Z
dc.date.available2016-01-24T14:30:53Z
dc.date.issued2013-01-01
dc.description.abstractPersistent high-risk (HR) human papillomavirus (HPV) infection is necessary for development of precursor lesions and cervical cancer. We investigate persistence and clearance of HPV infections and cofactors in unvaccinated women. Cervical samples of 569 women (18-75 years), received for routine evaluation in the Health Department of Ouro Preto, Brazil, were collected and subjected to PCR (MY09/11 orGP5+/6+ primers), followed by RFLP or sequencing. All women were interviewed to collect sociodemographic and behavioral information. Viral infection persistence or clearance was reevaluated after 24 months and was observed in 59.6% and 40.4% of women, respectively. HPVs 16, 33, 59, 66, 69, and 83 (HR) were the most persistent types whereas HPVs 31, 45, and 58 were less persistent. Clearance or persistence did not differ between groups infected by HPVs 18, 53, and 67. in low-risk (LR) types, HPV 6 infected samples were associated with clearance, while HPV 11, 61, 72, or 81 infected samples were persistent in the follow-up. No statistically significant association was detected between persistent HPV infections and sociodemographic and behavioral characteristics analyzed. To study persistence or clearance in HPV infection allows the identification of risk groups, cofactors, and strategies for prevention of cervical cancer.en
dc.description.affiliationInst Butantan, Genet Lab, BR-05503900 São Paulo, Brazil
dc.description.affiliationUniv Ouro Preto UFOP, Escola Farm, Dept Anal Clin, BR-35400000 Ouro Preto, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ginecol, Lab Tocoginecol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniv Fed Pernambuco UFPE, LIKA, BR-50670901 Recife, PE, Brazil
dc.description.affiliationUniv São Paulo, Programa Posgrad Interunidades Biotecnol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv Fed Integracao Latinoamer UNILA, Dept Biol, BR-85867970 Foz Do Iguacu, PR, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ginecol, Lab Tocoginecol, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPRONEX/FACEPE
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipFundação Butantan
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCNPq: 554816/2006-7
dc.description.sponsorshipIDPRONEX/FACEPE: APQ-0781-4.01/06
dc.description.sponsorshipIDFAPESP: 2006/02439-6
dc.format.extent6
dc.identifierhttps://dx.doi.org/10.1155/2013/578276
dc.identifier.citationBiomed Research International. New York: Hindawi Publishing Corporation, 6 p., 2013.
dc.identifier.doi10.1155/2013/578276
dc.identifier.fileWOS000327075100001.pdf
dc.identifier.issn2314-6133
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35697
dc.identifier.wosWOS:000327075100001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBiomed Research International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePersistence or Clearance of Human Papillomavirus Infections in Women in Ouro Preto, Brazilen
dc.typeinfo:eu-repo/semantics/article
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