Adiponectin complexes composition in Japanese-Brazilians regarding their glucose tolerance status

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dc.contributor.authorCrispim, Felipe [UNIFESP]
dc.contributor.authorVendramini, Marcio F. [UNIFESP]
dc.contributor.authorMoises, Regina S. [UNIFESP]
dc.contributor.authorJapanese Brazilian Diabetes Study Group
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:34Z
dc.date.available2016-01-24T14:31:34Z
dc.date.issued2013-04-09
dc.description.abstractBackground: Adiponectin circulates in different multimer complexes comprised of low molecular weight trimeric form (LMW), hexamer of middle molecular weight (MMW) and high molecular weight multimers (HMW). in Japanese-Brazilians, a population with high prevalence of glucose metabolism disturbances, we examined the associations of total adiponectin and its multimers with diabetes mellitus.Methods: Two study groups were examined: 26 patients with diabetes mellitus (DM, 14 women and 12 men, aged 55.3 +/- 8.6 years) and 27 age-matched control subjects with normal glucose tolerance (NGT, 12 women and 15 men, aged 54.0 +/- 9.2 years).Results: We found no significant differences in total [NGT: 6.90 ug/ml (4.38-13.43); DM: 5.38 ug/ml (3.76-8.56), p = 0.35], MMW [NGT: 2.34 ug/ml (1.38-3.25); DM: 1.80 ug/ml (1.18-2.84), p = 0.48] or LMW adiponectin [NGT: 2.07 ug/ml (1.45-3.48), DM: 2.93 ug/ml (1.78-3.99), p = 0.32] between groups. in contrast, HMW adiponectin levels were significantly lower in patients with DM [TGN: 2.39 ug/ml (1.20-4.75); DM: 1.04 ug/ml (0.42-1.60), p = 0.001]. A logistic regression analysis was done to identify independent associations with diabetes mellitus. the results showed that HOMA-IR and HMW adiponectin in women were independently associated with diabetes mellitus.Conclusion: the current investigation demonstrates that in Japanese-Brazilians HMW adiponectin is selectively reduced in individuals with type 2 diabetes, while no differences were found in MMW and LMW adiponectin isoforms.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Endocrinol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Endocrinol, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1186/1758-5996-5-20
dc.identifier.citationDiabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 5, 6 p., 2013.
dc.identifier.doi10.1186/1758-5996-5-20
dc.identifier.fileWOS000317646600001.pdf
dc.identifier.issn1758-5996
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36201
dc.identifier.wosWOS:000317646600001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofDiabetology & Metabolic Syndrome
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdiponectinen
dc.subjectHMW adiponectinen
dc.subjectJapanese-Braziliansen
dc.titleAdiponectin complexes composition in Japanese-Brazilians regarding their glucose tolerance statusen
dc.typeinfo:eu-repo/semantics/article
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