Ontogeny of complement regulatory proteins - Concentrations of factor H, factor I, C4b-binding protein, properdin and vitronectin in healthy children of different ages and in adults

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dc.contributor.authorPaula, P. F. de
dc.contributor.authorBarbosa, J. E.
dc.contributor.authorJunior, P. R.
dc.contributor.authorFerriani, Virginia Paes Leme [UNIFESP]
dc.contributor.authorLatorre, MRDO
dc.contributor.authorNudelman, Victor [UNIFESP]
dc.contributor.authorIsaac, L.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.date.accessioned2016-01-24T12:34:05Z
dc.date.available2016-01-24T12:34:05Z
dc.date.issued2003-11-01
dc.description.abstractPrevious studies of human in vivo complement protein levels have only compared data for neonates with that from adult sera. Here, we establish the normal concentration ranges of the following complement regulatory proteins in healthy Brazilian children of different age groups (neonates: 1 month-1 year, 1-6 years and 6-13 years) and in adults: factor H (fH), factor I (fI), C4b-binding protein (C4 BP), properdin and vitronectin. We found that the concentrations of fH, fI, properdin and vitronectin in neonates are significantly lower than in adults. Remarkably, the concentration of C4 BP is below the method resolution (<50 mug/ml) in 76% of the sera from neonates, while adults presented 199-532 mug/ml of C4 BP in their sera. the concentration of properdin in the sera from neonates and up to 1-year-old children was less than that observed in older children. Adults presented vitronectin levels significantly higher than all the other age groups in the study. No significant sex differences in the concentrations of all the studied regulatory proteins were detected. This study reveals the ontogeny of complement system in greater detail than previously available and may point to the reasons why neonates have higher susceptibility to develop life-threatening pyogenic infections. These reference values will be of use in clinical and laboratory investigations of disorders associated with low levels of these regulatory proteins.en
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Saude Publ, Dept Epidemiol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-05508900 São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent572-577
dc.identifierhttp://dx.doi.org/10.1046/j.1365-3083.2003.01326.x
dc.identifier.citationScandinavian Journal of Immunology. Oxford: Blackwell Publishing Ltd, v. 58, n. 5, p. 572-577, 2003.
dc.identifier.doi10.1046/j.1365-3083.2003.01326.x
dc.identifier.issn0300-9475
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27450
dc.identifier.wosWOS:000186303500010
dc.language.isoeng
dc.publisherBlackwell Publishing Ltd
dc.relation.ispartofScandinavian Journal of Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleOntogeny of complement regulatory proteins - Concentrations of factor H, factor I, C4b-binding protein, properdin and vitronectin in healthy children of different ages and in adultsen
dc.typeinfo:eu-repo/semantics/article
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