Cross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continents

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dc.contributor.authorCoplan, P. M.
dc.contributor.authorGupta, S. B.
dc.contributor.authorDubey, S. A.
dc.contributor.authorPitisuttithum, P.
dc.contributor.authorNikas, A.
dc.contributor.authorMbewe, B.
dc.contributor.authorVardas, E.
dc.contributor.authorSchechter, M.
dc.contributor.authorKallas, Esper Georges [UNIFESP]
dc.contributor.authorFreed, D. C.
dc.contributor.authorFu, T. M.
dc.contributor.authorMast, C. T.
dc.contributor.authorPuthavathana, P.
dc.contributor.authorKublin, J.
dc.contributor.authorCollins, K. B.
dc.contributor.authorChisi, J.
dc.contributor.authorPendame, R.
dc.contributor.authorThaler, S. J.
dc.contributor.authorGray, G.
dc.contributor.authorMcintyre, J.
dc.contributor.authorStraus, W. L.
dc.contributor.authorCondra, J. H.
dc.contributor.authorMehrotra, D. V.
dc.contributor.authorGuess, H. A.
dc.contributor.authorEmini, E. A.
dc.contributor.authorShiver, J. W.
dc.contributor.institutionMerck Res Labs
dc.contributor.institutionMahidol Univ
dc.contributor.institutionMalawi Coll Med
dc.contributor.institutionMinist Populat & Hlth
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Witwatersrand
dc.date.accessioned2016-01-24T12:37:48Z
dc.date.available2016-01-24T12:37:48Z
dc.date.issued2005-05-01
dc.description.abstractBackground. the genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the question of whether vaccines that include a component to elicit antiviral T cell immunity based on a single viral genetic clade could provide cellular immune protection against divergent HIV-1 clades. Therefore, we quantified the cross-clade reactivity, among unvaccinated individuals, of anti-HIV-1 T cell responses to the infecting HIV-1 clade relative to other major circulating clades.Methods. Cellular immune responses to HIV-1 clades A, B, and C were compared by standardized interferon-gamma enzyme-linked immunospot assays among 250 unvaccinated individuals, infected with diverse HIV-1 clades, from Brazil, Malawi, South Africa, Thailand, and the United States. Cross-clade reactivity was evaluated by use of the ratio of responses to heterologous versus homologous ( infecting) clades of HIV-1.Results. Cellular immune responses were predominantly focused on viral Gag and Nef proteins. Cross-clade reactivity of cellular immune responses to HIV-1 clade A, B, and C proteins was substantial for Nef proteins ( ratio, 0.97 [95% confidence interval, 0.89-1.05]) and lower for Gag proteins ( ratio, 0.67 [ 95% confidence interval, 0.62-0.73]). the difference in cross-clade reactivity to Nef and Gag proteins was significant (P < .0001).Conclusions. Cross-clade reactivity of cellular immune responses can be substantial but varies by viral protein.en
dc.description.affiliationMerck Res Labs, W Point, PA USA
dc.description.affiliationMahidol Univ, Bangkok 10700, Thailand
dc.description.affiliationMalawi Coll Med, Blantyre, Malawi
dc.description.affiliationMinist Populat & Hlth, Lilongwe, Malawi
dc.description.affiliationUniv Fed Rio de Janeiro, Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Witwatersrand, Johannesburg, South Africa
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1427-1434
dc.identifierhttp://dx.doi.org/10.1086/428450
dc.identifier.citationJournal of Infectious Diseases. Chicago: Univ Chicago Press, v. 191, n. 9, p. 1427-1434, 2005.
dc.identifier.doi10.1086/428450
dc.identifier.fileWOS000228128800008.pdf
dc.identifier.issn0022-1899
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28261
dc.identifier.wosWOS:000228128800008
dc.language.isoeng
dc.publisherUniv Chicago Press
dc.relation.ispartofJournal of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCross-reactivity of anti-HIV-1 T cell immune responses among the major HIV-1 clades in HIV-1-positive individuals from 4 continentsen
dc.typeinfo:eu-repo/semantics/article
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