Patterns of intravenous fluid resuscitation use in adult intensive care patients between 2007 and 2014: An international cross-sectional study

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dc.citation.issue5
dc.citation.volume12
dc.contributor.authorHammond, Naomi E.
dc.contributor.authorTaylor, Colman
dc.contributor.authorFinfer, Simon
dc.contributor.authorMachado, Flavia R. [UNIFESP]
dc.contributor.authorAn, YouZhong
dc.contributor.authorBillot, Laurent
dc.contributor.authorBloos, Frank
dc.contributor.authorBozza, Fernando
dc.contributor.authorCavalcanti, Alexandre Biasi
dc.contributor.authorCorrea, Maryam
dc.contributor.authorDu, Bin
dc.contributor.authorHjortrup, Peter B.
dc.contributor.authorLi, Yang
dc.contributor.authorMcIntryre, Lauralyn
dc.contributor.authorSaxena, Manoj
dc.contributor.authorSchortgen, Frederique
dc.contributor.authorWatts, Nicola R.
dc.contributor.authorMyburgh, John
dc.coverageSan Francisco
dc.date.accessioned2020-07-13T11:53:13Z
dc.date.available2020-07-13T11:53:13Z
dc.date.issued2017
dc.description.abstractBackground In 2007, the Saline versus Albumin Fluid Evaluation D Translation of Research Into Practice Study (SAFE-TRIPS) reported that 0.9% sodium chloride (saline) and hydroxyethyl starch (HES) were the most commonly used resuscitation fluids in intensive care unit (ICU) patients. Evidence has emerged since 2007 that these fluids are associated with adverse patient-centred outcomes. Based on the published evidence since 2007, we sought to determine the current type of fluid resuscitation used in clinical practice and the predictors of fluid choice and determine whether these have changed between 2007 and 2014. Methods In 2014, an international, cross-sectional study was conducted (Fluid-TRIPS) to document current patterns of intravenous resuscitation fluid use and determine factors associated with fluid choice. We examined univariate and multivariate associations between patients and prescriber characteristics, geographical region and fluid type. Additionally, we report secular trends of resuscitation fluid use in a cohort of ICUs that participated in both the 2007 and 2014 studies. Regression analysis were conducted to determine changes in the administration of crystalloid or colloid between 2007 and 2014. Findings In 2014, a total of 426 ICUs in 27 countries participated. Over the 24 hour study day, 1456/ 6707 (21.7%) patients received resuscitation fluid during 2716 resuscitation episodes. Crystalloids were administered to 1227/1456 (84.3%) patients during 2208/2716 (81.3%) episodes and colloids to 394/1456 (27.1%) patients during 581/2716 (21.4%) episodes. In multivariate analyses, practice significantly varied between geographical regions. Additionally, patients with a traumatic brain injury were less likely to receive colloid when compared to patients with no trauma (adjusted OR 0.24en
dc.description.abstract95% CI 0.1 to 0.62en
dc.description.abstractp = 0.003). Patients in the ICU for one or more days where more likely to receive colloid compared to patients in the ICU on their admission date (adjusted OR 1.75en
dc.description.abstract95% CI 1.27 to 2.41en
dc.description.abstractp = < 0.001). For secular trends in fluid resuscitation, 84 ICUs in 17 countries contributed data. In 2007, 527/1663 (31.7%) patients received fluid resuscitation during 1167 episodes compared to 491/1763 (27.9%) patients during 960 episodes in 2014. The use of crystalloids increased from 498/1167 (42.7%) in 2007 to 694/960 (72.3%) in 2014 (odds ratio (OR) 3.75, 95% confidence interval (CI) 2.95 to 4.77en
dc.description.abstractp = < 0.001), primarily due to a significant increase in the use of buffered salt solutions. The use of colloids decreased from 724/1167 (62.0%) in 2007 to 297/960 (30.9%) in 2014 (OR 0.29, 95% CI 0.19 to 0.43en
dc.description.abstractp = < 0.001), primarily due to a decrease in the use of HES, but an overall increase in the use of albumin. Conclusions Clinical practices of intravenous fluid resuscitation have changed between 2007 and 2014. Geographical location remains a strong predictor of the type of fluid administered for fluid resuscitation. Overall, there is a preferential use of crystalloids, specifically buffered salt solutions, over colloids. There is now an imperative to conduct a trial determining the safety and efficacy of these fluids on patient-centred outcomes.en
dc.description.affiliationGeorge Inst Global Hlth, Crit Care & Trauma Div, Sydney, NSW, Australia
dc.description.affiliationRoyal North Shore Hosp, Malcolm Fisher Dept Intens Care Med, Sydney, NSW, Australia
dc.description.affiliationUniv Sydney, Sydney Med Sch, Sydney, NSW, Australia
dc.description.affiliationUniv New South Wales, Fac Med, St George Clin Sch, Sydney, NSW, Australia
dc.description.affiliationUniv Fed Sao Paulo, Pain & Intens Care Dept, Anesthesiol, Sao Paulo, Brazil
dc.description.affiliationPeking Univ, Peoples Hosp, Dept Crit Care Med, Beijing, Peoples R China
dc.description.affiliationGeorge Inst Global Hlth, Stat Div, Sydney, NSW, Australia
dc.description.affiliationJena Univ Hosp, Dept Anesthesiol & Intens Care Med, Jena, Germany
dc.description.affiliationDOr Inst Res & Educ, Rio De Janeiro, Brazil
dc.description.affiliationHosp Coracao, Res Inst, Sao Paulo, Brazil
dc.description.affiliationBeijing Union Med Coll Hosp, Med Intens Care Unit, Beijing, Peoples R China
dc.description.affiliationCopenhagen Univ Hosp, Rigshosp, Dept Intens Care, Copenhagen, Denmark
dc.description.affiliationOttawa Hosp, Res Inst, Dept Med Crit Care, Ottawa, ON, Canada
dc.description.affiliationSt George Hosp, Dept Intens Care Med, Sydney, NSW, Australia
dc.description.affiliationReanimat Med Grp Hosp Henri Mondor, Assistance Publ Hop Paris, Creteil, France
dc.description.affiliationUnifespUniv Fed Sao Paulo, Pain & Intens Care Dept, Anesthesiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBaxter Healthcare
dc.description.sponsorshipCSL Behring
dc.description.sponsorshipNational Health and Medical Research Council of Australia
dc.description.sponsorshipIDNational Health and Medical Research Council of Australia: APP1039312
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0176292
dc.identifier.citationPlos One. San Francisco, v. 12, n. 5, p. -, 2017.
dc.identifier.doi10.1371/journal.pone.0176292
dc.identifier.fileWOS000401314500003.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54465
dc.identifier.wosWOS:000401314500003
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePatterns of intravenous fluid resuscitation use in adult intensive care patients between 2007 and 2014: An international cross-sectional studyen
dc.typeinfo:eu-repo/semantics/article
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