Paradoxical sleep deprivation activates hypothalamic nuclei that regulate food intake and stress response

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dc.contributor.authorLara Galvao, Milene de Oliveira [UNIFESP]
dc.contributor.authorSinigaglia-Coimbra, Rita [UNIFESP]
dc.contributor.authorKawakami, Suzi Emiko [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSuchecki, Deborah [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:43Z
dc.date.available2016-01-24T13:58:43Z
dc.date.issued2009-09-01
dc.description.abstractA large body of evidence has shown that prolonged paradoxical sleep deprivation (PSD) results in hypothalamic-pituitary-adrenal (HPA) axis activation, and in loss of body weight despite an apparent increase of food intake, reflecting increased energy expenditure. the flowerpot technique for PSD is an efficient paradigm for investigating the relationships among metabolic regulation and stress response. the purpose of the present study was to examine the mechanisms involved in the effects of 96 h of PSD on metabolism regulation, feeding behaviour and stress response by studying corticotrophin-releasing hormone (CRH) and orexin (ORX) immunoreactivity in specific hypothalamic nuclei. Once-daily assessments of body weight, twice-daily measurements of (spillage-corrected) food intake, and once-daily determinations of plasma adrenocorticotropic hormone (ACTH) and corticosterone were made throughout PSD or at corresponding times in control rats (CTL). Immunoreactivity for CRH in the paraventricular nucleus of the hypothalamus and for ORX in the hypothalamic lateral area was evaluated at the end of the experimental period. PSD resulted in increased diurnal, but not nocturnal, food intake, producing no significant changes in global food intake. PSD augmented the immunoreactivity for CRH and plasma ACTH and corticosterone levels, characterizing activation of the HPA axis. PSD also markedly increased the ORX immunoreactivity. the average plasma level of corticosterone correlated negatively with body weight gain throughout PSD. These results indicate that augmented ORX and CRH immunoreactivity in specific hypothalamic nuclei may underlie some of the metabolic changes consistently described in PSD. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Lab Neuropathol & Neuroprotect, Ctr Electron Microscopy, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Neuropathol & Neuroprotect, Ctr Electron Microscopy, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 98-14303/3
dc.format.extent1176-1183
dc.identifierhttp://dx.doi.org/10.1016/j.psyneuen.2009.03.003
dc.identifier.citationPsychoneuroendocrinology. Oxford: Pergamon-Elsevier B.V., v. 34, n. 8, p. 1176-1183, 2009.
dc.identifier.doi10.1016/j.psyneuen.2009.03.003
dc.identifier.issn0306-4530
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31788
dc.identifier.wosWOS:000269035400007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPsychoneuroendocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectParadoxical sleep deprivationen
dc.subjectFood intakeen
dc.subjectHypothalamusen
dc.subjectOrexinen
dc.subjectHPA axisen
dc.subjectStressen
dc.titleParadoxical sleep deprivation activates hypothalamic nuclei that regulate food intake and stress responseen
dc.typeinfo:eu-repo/semantics/article
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