Nucleus accumbens dopamine D-1 receptors regulate the expression of ethanol-induced behavioural sensitization

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dc.contributor.authorAbrahao, Karina Possa [UNIFESP]
dc.contributor.authorQuadros, Isabel Marian Hartmann
dc.contributor.authorSouza-Formigoni, Maria Lucia Oliveira de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTufts Univ
dc.date.accessioned2016-01-24T14:06:13Z
dc.date.available2016-01-24T14:06:13Z
dc.date.issued2011-03-01
dc.description.abstractRepeated ethanol administration may induce behavioural sensitization, defined as a progressive potentiation of locomotor stimulant effects. This process is associated with neuroadaptations in the mesolimbic pathway and the nucleus accumbens. the aim of the present study was to analyse dopamine D-1 receptor (D1R) participation in locomotor response to an agonist and an antagonist of the D1R in mice with different levels of sensitization to ethanol. in three separate experiments, mice received administrations of 2.2 g/kg ethanol or saline every other day for 10 d. According to their locomotor response on the last day, ethanol-treated animals were classified into two groups : sensitized or non-sensitized. After the treatment, mice were challenged with 4 or 8 mg/kg SKF-38393 (i.p.), a D1R agonist (expt 1); or with 0.01 or 0.1 mg/kg SCH-23390 (i.p.), a D1R antagonist, followed by 2.2 g/kg ethanol (i.p.) administration (expt 2). in expt 3, mice were challenged with intra-accumbens (intra-NAc) SKF-38393 (1 mu g/side, in 0.2 mu l), and with intra-NAc SCH-23390 (3 mu g/side, in 0.2 mu l) followed by 2.2 g/kg ethanol (i.p.). Although the i.p. administration of SKF-38393 did not affect the locomotion of mice, the intra-NAc administration of SKF-38393 significantly increased the locomotor activity in sensitized mice, suggesting that sensitized mice present functionally hyperresponsive D(1)Rs in the NAc. Both i.p. and intra-NAc administration of SCH-23390 blocked the expression of ethanol sensitization, suggesting that the activation of NAc D(1)Rs seems to be essential for the expression of ethanol sensitization.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationTufts Univ, Dept Neurosci, Neurosci Res Ctr, Boston, MA 02111 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: FAPESP 04/14834-1
dc.description.sponsorshipIDCNPq: CNPq 301321/2006-0
dc.format.extent175-185
dc.identifierhttp://dx.doi.org/10.1017/S1461145710000441
dc.identifier.citationInternational Journal of Neuropsychopharmacology. New York: Cambridge Univ Press, v. 14, n. 2, p. 175-185, 2011.
dc.identifier.doi10.1017/S1461145710000441
dc.identifier.issn1461-1457
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33486
dc.identifier.wosWOS:000287786000003
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofInternational Journal of Neuropsychopharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectBehavioural sensitizationen
dc.subjectD-1 receptorsen
dc.subjectethanolen
dc.subjectmiceen
dc.subjectnucleus accumbensen
dc.titleNucleus accumbens dopamine D-1 receptors regulate the expression of ethanol-induced behavioural sensitizationen
dc.typeinfo:eu-repo/semantics/article
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