Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

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dc.citation.volume7
dc.contributor.authorPeres, Fernanda Fiel [UNIFESP]
dc.contributor.authorLeyin, Raquel [UNIFESP]
dc.contributor.authorSuiama, Mayra Akimi [UNIFESP]
dc.contributor.authorDiana, Mariana Cepollaro [UNIFESP]
dc.contributor.authorGouvea, Douglas Albuquerque [UNIFESP]
dc.contributor.authorAlmeida, Valeria [UNIFESP]
dc.contributor.authorSantos, Camila Mauricio [UNIFESP]
dc.contributor.authorLungato, Lisandro [UNIFESP]
dc.contributor.authorZuardi, Antonio W.
dc.contributor.authorHallak, Jaime E. C.
dc.contributor.authorCrippa, Jose A.
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.contributor.authorSilva, Regina Helena da [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-31T12:47:48Z
dc.date.available2020-07-31T12:47:48Z
dc.date.issued2016
dc.description.abstractCannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of reserpine in rodents induces motor impairments that are accompanied by cognitive deficits, and has been applied to model both tardive dyskinesia and Parkinson's disease. The present study investigated whether CBD administration would attenuate reserpine-induced motor and cognitive impairments in rats. Male Wistar rats received four injections of CBD (0.5 or 5 mg/kg) or vehicle (days 2-5). On days 3 and 5, animals received also one injection of 1 mg/kg reserpine or vehicle. Locomotor activity, vacuous chewing movements, and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated animals' performance on the plus-maze discriminative avoidance task, for learning/memory assessment. CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion induced by reserpine. CBD (0.5 mg/kg) also ameliorated the reserpine-induced memory deficit in the discriminative avoidance task. Our data show that CBD is able to attenuate motor and cognitive impairments induced by reserpine, suggesting the use of this compound in the pharmacotherapy of Parkinson's disease and tardive dyskinesia.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Neurosci & Behav, Ribeirao Preto, Brazil
dc.description.affiliationNatl Council Sci & Technol Dev, Natl Inst Translat Med, Ribeirao Preto, Brazil
dc.description.affiliationUnifespInterdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Pharmacology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2010/07994-3
dc.description.sponsorshipIDFAPESP: 2015/03354-3
dc.description.sponsorshipIDCNPq/MS/SCTIE/DECIT: 26/2014
dc.description.sponsorshipIDCNPq/MS/SCTIE/DECIT: 466805/2014-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fphar.2016.00343
dc.identifier.citationFrontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fphar.2016.00343
dc.identifier.fileWOS000384265900001.pdf
dc.identifier.issn1663-9812
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57099
dc.identifier.wosWOS:000384265900001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectreserpineen
dc.subjectcannabidiolen
dc.subjectParkinson's diseaseen
dc.subjecttardive dyskinesiaen
dc.subjectschizophreniaen
dc.subjectraten
dc.titleCannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Ratsen
dc.typeinfo:eu-repo/semantics/article
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