Telomere length as a marker of sleep loss and sleep disturbances: a potential link between sleep and cellular senescence

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dc.contributor.authorTempaku, Priscila F. [UNIFESP]
dc.contributor.authorMazzotti, Diego R. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:40:28Z
dc.date.available2016-01-24T14:40:28Z
dc.date.issued2015-05-01
dc.description.abstractThe identification of biological markers that allow the early diagnosis, or even the prevention of age-related diseases, is an important goal that is being actively pursued in the research community. Sleep is one of the physiological processes that is most affected by aging, and there is a strong relationship between age-related sleep alterations and diseases. Changes in cellular senescence and the linked changes in telomere length might be potential markers of age-related sleep changes. in this review, we present some of the most recent evidence showing that telomere length has been associated with sleep loss and sleep disturbances in cross-sectional and case-control studies. We also present insights into the cellular senescence mechanisms relating to changes in telomere length, and we suggest that this field lacks basic and clinical research studies, especially long-term longitudinal studies, which may bring opportunities to sleep researchers to investigate this relationship in more depth. (C) 2015 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent559-563
dc.identifierhttp://dx.doi.org/10.1016/j.sleep.2015.02.519
dc.identifier.citationSleep Medicine. Amsterdam: Elsevier B.V., v. 16, n. 5, p. 559-563, 2015.
dc.identifier.doi10.1016/j.sleep.2015.02.519
dc.identifier.issn1389-9457
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39055
dc.identifier.wosWOS:000353892800004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofSleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleepen
dc.subjectTelomere lengthen
dc.subjectSleep lossen
dc.subjectCellular senescenceen
dc.titleTelomere length as a marker of sleep loss and sleep disturbances: a potential link between sleep and cellular senescenceen
dc.typeinfo:eu-repo/semantics/article
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