Open oral food challenge in the confirmation of cow's milk allergy mediated by immunoglobulin E

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dc.contributor.authorMendonça, Raquel Bicudo [UNIFESP]
dc.contributor.authorMotta Franco, J.
dc.contributor.authorCocco, Renata Rodrigues [UNIFESP]
dc.contributor.authorSuano de Souza, F. I. [UNIFESP]
dc.contributor.authorLopes de Oliveira, L. C. [UNIFESP]
dc.contributor.authorSarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.authorSolé, Dirceu [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Sergipe
dc.date.accessioned2016-01-24T14:17:42Z
dc.date.available2016-01-24T14:17:42Z
dc.date.issued2012-01-01
dc.description.abstractBackground: the most reliable method to diagnose food allergy or to determine tolerance is the oral food challenge.Objectives: the aim of this study was to describe the open oral food challenge applied to children with suspicion of cow's milk allergy mediated by immunoglobulin E, and evaluate the relation between the clinical history and skin prick test with the challenge outcomes. Patients and methods: Forty-six children (median age 13.8 months), with clinical history of immediate reactions to cow's milk and positive skin prick test, underwent an open oral food challenge with cow's milk.Results: the challenge was positive in 41.3%. Cutaneous reactions were the most common (73.7%), followed by respiratory (57.9%) and gastrointestinal reactions (36.8%). According to the severity of the reactions, 57.9%, 36.8% and 5.3% had mild, moderate and severe reactions, respectively. Oral antihistamine was sufficient as treatment in all positive cases. A higher frequency of positive skin prick test with total milk and casein was observed in children with positive oral food challenge. There was a significant agreement between the reactions reported by the family history and those observed during the challenge for 68.4% of children with positive results (Kappa = 0.728; p < 0.001).Conclusions: the method was considered suitable for children up to three years of age, and is safe and easy to perform. There was a significant correlation between the clinical history and the challenge outcomes. A positive skin prick test with total milk and casein was significantly associated with positive challenge results. (C) 2010 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.en
dc.description.affiliationFed Univ São Paulo UNIFESP EPM, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil
dc.description.affiliationUniv Fed Sergipe, Dept Med & Post Grad Nucleus Med, Aracaju, Sergipe, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP EPM, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent25-30
dc.identifierhttp://dx.doi.org/10.1016/j.aller.2011.02.007
dc.identifier.citationAllergologia Et Immunopathologia. Barcelona: Elsevier Doyma Sl, v. 40, n. 1, p. 25-30, 2012.
dc.identifier.doi10.1016/j.aller.2011.02.007
dc.identifier.issn0301-0546
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34445
dc.identifier.wosWOS:000299717000006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAllergologia Et Immunopathologia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectChildrenen
dc.subjectCow's milk allergyen
dc.subjectDiagnosis of food allergyen
dc.subjectMilk hypersensitivityen
dc.subjectOral food challengeen
dc.titleOpen oral food challenge in the confirmation of cow's milk allergy mediated by immunoglobulin Een
dc.typeinfo:eu-repo/semantics/article
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