Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer

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dc.contributor.authorTeixeira, Daniela [UNIFESP]
dc.contributor.authorAlmeida, Joaquim Soares de [UNIFESP]
dc.contributor.authorVisniauskas, Bruna [UNIFESP]
dc.contributor.authorGomes, Guiomar Nascimento [UNIFESP]
dc.contributor.authorHirata, Aparecida Emiko [UNIFESP]
dc.contributor.authorBueno, Valquiria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:45:30Z
dc.date.available2015-06-14T13:45:30Z
dc.date.issued2013-06-01
dc.description.abstractOBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy. Identifying myeloid-derived suppressor cells and associated factors is the first step in creating strategies to reverse the suppressive effects of these cells on the immune system. METHODS: To induce lung cancer, we administered 2 doses of urethane to BALB/c mice and observed these animals for 120 days. After this period, we evaluated the percentage of myeloid-derived suppressor cells in the blood, lung and bone marrow. The expression of alpha-smooth muscle actin, transforming growth factor-β, Toll-like receptor 2, Toll-like receptor 4, and interleukin-6 was also determined in the lung tissue. RESULTS: Myeloid-derived suppressor cells were increased in all evaluated tissues after lung cancer development in association with increased Toll-like receptor 4 expression and decreased interleukin-6 expression in the lung. We observed alpha-smooth muscle actin and transforming growth factor-β expression in lung nodules. CONCLUSIONS: We believe that the early diagnosis of cancer through determining the blood levels of myeloid-derived suppressor cells followed by the depletion of these cells should be further investigated as a possible approach for cancer treatment.en
dc.description.affiliationFederal University of São Paulo Immunology Division
dc.description.affiliationFederal University of São Paulo Pathology Division
dc.description.affiliationFederal University of São Paulo Psychobiology Division
dc.description.affiliationFederal University of São Paulo Physiology Division
dc.description.affiliationUnifespUNIFESP, Immunology Division
dc.description.affiliationUnifespUNIFESP, Pathology Division
dc.description.affiliationUnifespUNIFESP, Psychobiology Division
dc.description.affiliationUnifespUNIFESP, Physiology Division
dc.description.sourceSciELO
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP
dc.description.sponsorshipConselho Nacional de Pesquisa (CNPq)
dc.format.extent858-864
dc.identifierhttp://dx.doi.org/10.6061/clinics/2013(06)22
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 68, n. 6, p. 858-864, 2013.
dc.identifier.doi10.6061/clinics/2013(06)22
dc.identifier.fileS1807-59322013000600858.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322013000600858
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/7834
dc.identifier.wosWOS:000320463800022
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLung Canceren
dc.subjectMyeloid-Derived Suppressor Cellsen
dc.subjectToll-Like Receptorsen
dc.subjectCytokinesen
dc.subjectFibroblastsen
dc.titleMyeloid-derived suppressor cells and associated events in urethane-induced lung canceren
dc.typeinfo:eu-repo/semantics/article
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