Postnatal fluoxetine treatment affects the development of serotonergic neurons in rats

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dc.contributor.authorMendes-da-Silva, Cristiano [UNIFESP]
dc.contributor.authorGonçalves, Luciano
dc.contributor.authorManhães-de-Castro, Raul
dc.contributor.authorNogueira, Maria Ines
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.date.accessioned2016-01-24T14:05:34Z
dc.date.available2016-01-24T14:05:34Z
dc.date.issued2010-10-15
dc.description.abstractThe goal of the present study was to investigate morphological changes in the serotonergic neurons/terminals in the dorsal (DR) and median (MnR) raphe nuclei and on the hippocampal dentate gyrus (DG) in neonatal rats treated from the 1st to the 21st postnatal day with fluoxetine (10 mg/kg sc, daily) or drug vehicle (0 9% saline 1 ml/kg). the results show that postnatal chronic treatment with fluoxetine promoted. (1) a smaller body weight increase during the pre-weaning period; (2) smaller number of 5-HT neurons in the DR, (3) smaller 5-HT neuronal cell bodies (area, perimeter and diameter) in the DR and the MnR and (4) diminished serotonergic terminals in the DG. These data suggest that the development of the serotonergic system was impaired and that early exposure to fluoxetine damaged the morphology of 5-HT neurons in young adult rats While these findings are consistent with other work, more studies are needed to better clarify the effects of postnatal chronic treatment with fluoxetine on the serotonergic system and, consequently, on the functions modulated by serotonin (C) 2010 Elsevier Ireland Ltd All rights reserveden
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv Fed Pernambuco, Ctr Hlth Sci, Dept Nutr, BR-50670901 Recife, PE, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Anat, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent179-183
dc.identifierhttps://dx.doi.org/10.1016/j.neulet.2010.08.003
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 483, n. 3, p. 179-183, 2010.
dc.identifier.doi10.1016/j.neulet.2010.08.003
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/32992
dc.identifier.wosWOS:000282205500005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSerotonergic neuronsen
dc.subjectRaphe nucleien
dc.subjectDentate gyrusen
dc.subjectFluoxetine postnatalen
dc.subjectMorphologyen
dc.subjectProgrammingen
dc.titlePostnatal fluoxetine treatment affects the development of serotonergic neurons in ratsen
dc.typeinfo:eu-repo/semantics/article
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