The anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000 (TM)) on 2,4,6-trinitrobenzene sulphonic acid-induced colitis

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dc.contributor.authorRibeiro Paiotti, Ana Paula [UNIFESP]
dc.contributor.authorNeto, Ricardo Artigiani [UNIFESP]
dc.contributor.authorMarchi, Patricia [UNIFESP]
dc.contributor.authorSilva, Roseane Mendes [UNIFESP]
dc.contributor.authorPazine, Vanessa Lima [UNIFESP]
dc.contributor.authorNoguti, Juliana [UNIFESP]
dc.contributor.authorPastrelo, Mauricio Mercaldi [UNIFESP]
dc.contributor.authorBoiago Golluecke, Andrea Pittelli
dc.contributor.authorMiszputen, Sender Jankiel [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T14:34:26Z
dc.date.available2016-01-24T14:34:26Z
dc.date.issued2013-09-28
dc.description.abstractChronic inflammatory bowel disease is characterised by an up-regulation of the synthesis and release of a variety of pro-inflammatory mediators leading to excessive tissue injury. Flavonoids are able to inhibit enzymes and/or due to their antioxidant properties regulate the immune response. the goal of the present study was to evaluate the mechanisms of action of phenolic compounds present in grape juice on 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. A total of forty-one male Wistar rats were randomised into seven groups: negative control group; TNBS non-treated induced colitis; 2% grape juice control group; 1% grape juice 24 h after TNBS colitis induction; 1% grape juice on day 7 after colitis induction; 2% grape juice 24 h after colitis induction; 2% grape juice on day 7 after colitis induction. the 1% grape juice-treated induced colitis group showed marked clinical improvement when compared with the TNBS-induced colitis group. Rats that received 1% grape juice, on day 7 after colitis induction, presented reduced intensity of macroscopic and histological scores. Statistically significant differences (P<0.05) of TNF-alpha and inducible NO synthase mRNA expression were detected in the groups treated with grape juice at the 1% dose after inducing experimental colitis when compared with the TNBS group. Grape juice reduced the noxious effects induced by colitis caused by TNBS, especially at the 1% dose.en
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Dept Pathol, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Div Gastroenterol, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Food Engn Fac, Dept Food & Nutr, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Dept Pathol, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Div Gastroenterol, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent973-980
dc.identifierhttp://dx.doi.org/10.1017/S000711451300007X
dc.identifier.citationBritish Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 110, n. 6, p. 973-980, 2013.
dc.identifier.doi10.1017/S000711451300007X
dc.identifier.issn0007-1145
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36766
dc.identifier.wosWOS:000323848700001
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofBritish Journal of Nutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subject2,4,6-Trinitrobenzene sulphonic acid-induced colitisen
dc.subjectGrape juiceen
dc.subjectTNF-alphaen
dc.subjectInducible nitric oxide synthaseen
dc.subjectIntercellular adhesion molecule-1en
dc.subjectNF-kappa Ben
dc.titleThe anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000 (TM)) on 2,4,6-trinitrobenzene sulphonic acid-induced colitisen
dc.typeinfo:eu-repo/semantics/article
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