Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer's disease dementia

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dc.citation.issue2
dc.citation.volume39
dc.contributor.authorde Oliveira, Fabricio F. [UNIFESP]
dc.contributor.authorChen, Elizabeth S. [UNIFESP]
dc.contributor.authorSmith, Marilia C. [UNIFESP]
dc.contributor.authorBertolucci, Paulo H. [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:02:24Z
dc.date.available2020-07-17T14:02:24Z
dc.date.issued2017
dc.description.abstractObjective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer's disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs1 1669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. Results: Considering 201 patients, only APOE-epsilon 4 carriers had earlier dementia onset in multiple correlations, as well as less apathy, more delusions, and more aberrant motor behavior. Both ACE polymorphisms were associated with less intense frontally mediated behaviors. Regarding LDLR variants, carriers of the A allele of rs1 1669576 had less anxiety and more aberrant motor behavior, whereas carriers of the A allele of rs5930 had less delusions, less anxiety, more apathy, and more irritability. CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. Conclusion: Though only APOE haplotypes affected AD onset, cerebrovascular metabolism genotypes were associated with differences in several neuropsychiatric manifestations of AD.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, EPM, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, EPM, Dept Morfol & Genet, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, EPM, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, EPM, Dept Morfol & Genet, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCAPES
dc.description.sponsorshipFAPESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipIDCAPES: 1067/10
dc.description.sponsorshipIDFAPESP: 2015/10109-5
dc.format.extent95-103
dc.identifierhttp://dx.doi.org/10.1590/1516-4446-2016-1991
dc.identifier.citationRevista Brasileira De Psiquiatria. Sao Paulo, v. 39, n. 2, p. 95-103, 2017.
dc.identifier.doi10.1590/1516-4446-2016-1991
dc.identifier.fileS1516-44462017000200095.pdf
dc.identifier.issn1516-4446
dc.identifier.scieloS1516-44462017000200095
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54785
dc.identifier.wosWOS:000403273400004
dc.language.isoeng
dc.publisherAssoc Brasileira Psiquiatria
dc.relation.ispartofRevista Brasileira De Psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer diseaseen
dc.subjectdementiaen
dc.subjectcerebrovascular disordersen
dc.subjectgeneticsen
dc.subjectneuropsychiatryen
dc.titleAssociations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer's disease dementiaen
dc.typeinfo:eu-repo/semantics/article
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