Comparative Study of Conjunctival Limbal Transplantation Not Associated With the Use of Amniotic Membrane Transplantation for Treatment of Total Limbal Deficiency Secondary to Chemical Injury

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dc.contributor.authorBarreiro, Telma P. [UNIFESP]
dc.contributor.authorSantos, Myrna S. [UNIFESP]
dc.contributor.authorVieira, Ana C. [UNIFESP]
dc.contributor.authorBarros, Jeison de Nadai [UNIFESP]
dc.contributor.authorHazarbassanov, Rossen M. [UNIFESP]
dc.contributor.authorGomes, José Álvaro Pereira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:34Z
dc.date.available2016-01-24T14:37:34Z
dc.date.issued2014-07-01
dc.description.abstractPurpose:The aim of this study was to compare the outcome of conjunctival limbal transplantation with and without the use of amniotic membrane (AM) transplantation for the treatment of limbal deficiency after chemical burns to the eyes.Methods:This is a retrospective, comparative, interventional case series that included 34 eyes (34 patients) with total limbal deficiency after chemical burns, who were submitted to conjunctival limbal transplantation. Two groups were formed: group 1 (15 eyes) limbal transplantation associated with AM transplantation and group 2 (19 eyes) only limbal transplantation. Success and failure rates, epithelialization time, and visual acuity were compared between the 2 groups.Results:The mean follow-up period was 19.71 5.6 months in group 1 and 18.26 +/- 7.78 months in group 2. the proportion of conjunctival limbal autograft and living-related conjunctival limbal allograft was similar in both groups (P = 0.914). Time until complete epithelialization of the corneal surface was significantly longer in group 1 (P = 0.007). Graft survival was similar in both groups (P = 0.581). Failure rate was also similar in both groups (P = 0.232). the most common cause of failure was transplanted stem cell depletion in group 1 (20% of cases) and rejection in group 2 (10.5%). the visual acuity improved postoperatively in 12 eyes (80%) in group 1 and 16 (84.2%) in group 2 (P = 0.430).Conclusions:Results with the use of AM associated with conjunctival limbal transplantation in ocular surface reconstruction were similar to those obtained with limbal transplantation alone. Both techniques were found to be satisfactory for ocular surface reconstruction in patients with total limbal deficiency after chemical burns.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent716-720
dc.identifierhttp://dx.doi.org/10.1097/ICO.0000000000000139
dc.identifier.citationCornea. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 7, p. 716-720, 2014.
dc.identifier.doi10.1097/ICO.0000000000000139
dc.identifier.issn0277-3740
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37966
dc.identifier.wosWOS:000337748400014
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCornea
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectconjunctival limbal transplantationen
dc.subjectamniotic membrane transplantationen
dc.subjectlimbal deficiencyen
dc.titleComparative Study of Conjunctival Limbal Transplantation Not Associated With the Use of Amniotic Membrane Transplantation for Treatment of Total Limbal Deficiency Secondary to Chemical Injuryen
dc.typeinfo:eu-repo/semantics/article
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