Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses

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dc.contributor.authorDiniz, Leila [UNIFESP]
dc.contributor.authorReis, Bianca Beraldo dos [UNIFESP]
dc.contributor.authorCastro, Glaucia Monteiro de [UNIFESP]
dc.contributor.authorMedalha, Carla Christina [UNIFESP]
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:43:16Z
dc.date.available2015-06-14T13:43:16Z
dc.date.issued2011-10-01
dc.description.abstractIt is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the experiments, N = 6-10/group) tested in the elevated T-maze (ETM). These defensive behaviors have been associated with generalized anxiety and panic disorder, respectively. Since the tricyclic antidepressant imipramine is successfully used to treat both conditions, the effects of combined treatment with chronic imipramine (15 mg, ip) and CORT were also investigated. Results showed that chronic CORT facilitated avoidance performance, an anxiogenic-like effect (P < 0.05), without changing escape responses. Imipramine significantly reversed the anxiogenic effect of CORT (P < 0.05), although the drug did not exhibit anxiolytic effects by itself. Confirming previous observations, imipramine inhibited escape responses, a panicolytic-like effect. Unlike chronic CORT, imipramine also decreased locomotor activity in an open field. These data suggest that chronic CORT specifically altered ETM avoidance, a fact that should be relevant to a better understanding of the physiopathology of generalized anxiety and panic disorder.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Psiquiatria
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Biociências
dc.description.affiliationUnifespUNIFESP, Depto. de Psiquiatria
dc.description.affiliationUnifespUNIFESP, Depto. de Biociências
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipIDFAPESP: 2008/58815-1pt
dc.description.sponsorshipIDFAPESP: 2009/50830-4pt
dc.format.extent1048-1053
dc.identifierhttps://dx.doi.org/10.1590/S0100-879X2011007500117
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1048-1053, 2011.
dc.identifier.doi10.1590/S0100-879X2011007500117
dc.identifier.fileS0100-879X2011001000010.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2011001000010
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/6628
dc.identifier.wosWOS:000295721600010
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCorticosteroneen
dc.subjectImipramineen
dc.subjectGeneralized anxiety disorderen
dc.subjectPanic disorderen
dc.subjectElevated T-mazeen
dc.titleEffects of chronic corticosterone and imipramine administration on panic and anxiety-related responsesen
dc.typeinfo:eu-repo/semantics/article
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