Assessing cardiovascular risk in ATM heterozygotes

Página do item simplificado
dc.citation.issue2
dc.citation.volume64
dc.contributor.authorde Almeida Kotchetkoff, Elaine Cristina [UNIFESP]
dc.contributor.authorSuano de Souza, Fabiola Isabel [UNIFESP]
dc.contributor.authorAffonso Fonseca, Fernando Luiz [UNIFESP]
dc.contributor.authorHix, Sonia
dc.contributor.authorAjzen, Sergio Aron [UNIFESP]
dc.contributor.authorShigueoka, David Carlos [UNIFESP]
dc.contributor.authorCosta Carvalho, Beatriz Tavares [UNIFESP]
dc.contributor.authorSaccardo Sarni, Roseli Oselka [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-08T13:09:42Z
dc.date.available2020-07-08T13:09:42Z
dc.date.issued2018
dc.description.abstractObjective: To evaluate the carotid intima-media complex (CIMC) thickness and lipid metabolism biomarkers associated with cardiovascular risk (CR) in parents of patients with ataxia-telangiectasia and verify an association with gender. Method: A cross-sectional and controlled study with 29 ATM heterozygotes and 14 healthy controls. Biochemical tests and CIMC thickness measurement were performed. Results: The mean CIMC measurement in heterozygous ATM was 0.72 +/- 0.1 mm (minimum: 0.5 mm and maximum: 1.0 mm). Noticed high percentage of amounts above 75 percentile compared to the population referential (16 [76.2%]), without any significant statistical differences between the female and the male gender (11/15 [73.3%] vs. 5/6 [83.3%]en
dc.description.abstractp=0.550). The comparison between heterozygous and controls, stratified by gender, showed that in heterozygous ATMs, women had higher concentrations of HDL-c compared to men, as well as higher values of hs-CRP in relation to the control women. In heterozygous ATMs, stratified by gender, the correlation between HDL-c and hs-CRP was inversely proportional and stronger among women, with a tendency to statistical significance. Conclusion: Heterozygous ATMs did not differ from controls in relation to the biomarkers studied related to CR. However, most of them presented increased CIMC, independent predictor of death, risk for myocardial infarction and stroke, compared to the referential for the same age group. This finding suggests CR in the heterozygous ATM and shows to the need to monitor CIMC thickness and nutritional orientations.en
dc.description.affiliationUniv Fed Sao Paulo EPM Unifesp, Escola Paulista Med, Pediat Dept, Sao Paulo, SP, Brazil
dc.description.affiliationFac Med ABC FMABC, Santo Andre, SP, Brazil
dc.description.affiliationUnifesp, Diadema, SP, Brazil
dc.description.affiliationFMABC, Dept Morphol & Physiol, Santo Andre, SP, Brazil
dc.description.affiliationEPM Unifesp, Dept Diagnost Imaging, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo EPM Unifesp, Escola Paulista Med, Pediat Dept, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUnifesp, Diadema, SP, Brazil
dc.description.affiliationUnifespEPM Unifesp, Dept Diagnost Imaging, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent148-153
dc.identifierhttp://dx.doi.org/10.1590/1806-9282.64.02.148
dc.identifier.citationRevista Da Associacao Medica Brasileira. Sao Paulo, v. 64, n. 2, p. 148-153, 2018.
dc.identifier.doi10.1590/1806-9282.64.02.148
dc.identifier.fileS0104-42302018000200148.pdf
dc.identifier.issn0104-4230
dc.identifier.scieloS0104-42302018000200148
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54153
dc.identifier.wosWOS:000429487700011
dc.language.isoeng
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtaxia Telangiectasiaen
dc.subjectAtherosclerosisen
dc.subjectCarotid Intima-Media Thicknessen
dc.subjectInsulin Resistanceen
dc.subjectHeterozygoteen
dc.titleAssessing cardiovascular risk in ATM heterozygotesen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos
ICAQF - Artigos