Role of the caudal pressor area in the regulation of sympathetic vasomotor tone

dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorCarillo, Bruno de Arruda [UNIFESP]
dc.contributor.authorOliveira-Sales, Elizabeth Barbosa de [UNIFESP]
dc.contributor.authorSilva, Adilson Marques da [UNIFESP]
dc.contributor.authorSilva, Nyam Florencio da
dc.contributor.authorFuturo Neto, Henrique Azevedo
dc.contributor.authorBergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Espírito Santo Laboratório de Neuromorfologia
dc.contributor.institutionUniversidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências Fisiológicas
dc.contributor.institutionSanta Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de Ciências
dc.date.accessioned2015-06-14T13:38:38Z
dc.date.available2015-06-14T13:38:38Z
dc.date.issued2008-07-01
dc.description.abstractIt is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Fisiologia Cardiovascular e Respiratória
dc.description.affiliationUniversidade Federal do Espírito Santo Laboratório de Neuromorfologia
dc.description.affiliationUniversidade Federal do Espírito Santo Programa de Pós-Graduação em Ciências Fisiológicas
dc.description.affiliationSanta Casa de Misericórdia de Vitória (EMESCAM) Escola Superior de Ciências
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Campus Baixada Santista Departamento de Biociênicas
dc.description.affiliationUnifespUNIFESP, EPM, Disciplina de Fisiologia Cardiovascular e Respiratória
dc.description.affiliationUnifespUNIFESP, Campus Baixada Santista Depto. de Biociênicas
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent557-562
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2008000700002
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 7, p. 557-562, 2008.
dc.identifier.doi10.1590/S0100-879X2008000700002
dc.identifier.fileS0100-879X2008000700002.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2008000700002
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4465
dc.identifier.wosWOS:000259326100002
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRostral ventrolateral medullaen
dc.subjectRaten
dc.subjectGlutamateen
dc.subjectBlood pressureen
dc.subjectCaudal pressor areaen
dc.subjectSympathetic vasomotor toneen
dc.titleRole of the caudal pressor area in the regulation of sympathetic vasomotor toneen
dc.typeinfo:eu-repo/semantics/article
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