Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

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dc.citation.issue4]
dc.citation.volume20]
dc.contributor.authorSiqueira, Lilian [UNIFESP]
dc.contributor.authorde Paula, Cynthia Guimaraes [UNIFESP]
dc.contributor.authorMotisuke, Mariana [UNIFESP]
dc.contributor.authorGouveia, Rubia Figueredo
dc.contributor.authorAfonso Camargo, Samira Esteves
dc.contributor.authorMoreira Milhan, Noala Vicensoto
dc.contributor.authorTriches, Eliandra de Sousa [UNIFESP]
dc.coverageSao Carlos
dc.date.accessioned2020-06-26T16:30:23Z
dc.date.available2020-06-26T16:30:23Z
dc.date.issued2017
dc.description.abstractReplacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. beta-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, beta-TCP and beta-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (8688%) and pore sizes ranging from 200 to 500 mu m. Even though alumina did not promote improvement in beta-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, beta-TCP and beta-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Sci & Technol Inst ICT, Bioceram Lab BIOCERAM, 330 Talim St, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationCNPEM, Brazilian Nanotechnol Natl Lab LNNANO, POB 6192, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquita Filho UN, Sch Dent, Dept Biosci & Oral Diag, 777 Engenheiro Francisco Jose Longo Ave, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Sci & Technol Inst ICT, Bioceram Lab BIOCERAM, 330 Talim St, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation - FAPESP
dc.description.sponsorshipNational Council for Scientific and Technological Development
dc.description.sponsorshipNational Council for Scientific and Technological Development
dc.description.sponsorshipIDFAPESP: 2010/00863-0
dc.description.sponsorshipIDNational Council for Scientific and Technological Development: 456461/2014-0]
dc.description.sponsorshipIDCNPq/PIBITI/UNIFESP
dc.format.extent973-983
dc.identifierhttp://dx.doi.org/10.1590/1980-5373-MR-2016-0467]
dc.identifier.citationMaterials Research-Ibero-American Journal Of Materials. Sao Carlos, v. 20, n. 4, p. 973-983, 2017.
dc.identifier.doi10.1590/1980-5373-MR-2016-0467
dc.identifier.fileS1516-14392017000400973.pdf
dc.identifier.issn1516-1439
dc.identifier.scieloS1516-14392017000400973
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53521
dc.identifier.wosWOS:000410628100016
dc.language.isoeng
dc.publisherUniv Fed Sao Carlos, Dept Engenharia Materials
dc.relation.ispartofMaterials Research-Ibero-American Journal Of Materials
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTricalcium phosphateen
dc.subjectaluminaen
dc.subjectgel-casting methoden
dc.subjectcytocompatibilityen
dc.subjectscaffoldsen
dc.titlePreparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foamsen
dc.typeinfo:eu-repo/semantics/article
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