Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial

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dc.citation.issue1
dc.citation.volume9
dc.contributor.authorKamamoto, C. S. L. [UNIFESP]
dc.contributor.authorNishikaku, A. S. [UNIFESP]
dc.contributor.authorGompertz, O. F. [UNIFESP]
dc.contributor.authorMelo, A. S. [UNIFESP]
dc.contributor.authorHassun, K. M. [UNIFESP]
dc.contributor.authorBagatin, E. [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-08-04T13:39:48Z
dc.date.available2020-08-04T13:39:48Z
dc.date.issued2017
dc.description.abstractMalassezia spp in skin microbiome scalp has been implicated in seborrheic dermatitis pathogenesis. Thus, treatment based in antifungal combined to topical keratolitic agents have been indicated as well as oral isotretinoin as it reduces the sebum production, glandular's size and possesses antiinflammatory properties. This randomized, comparative and therapeutic trial aimed toper form the genotypic identification of Malassezia species before and after low-dose oral isotretinoin or topical antifungal treatments for moderate to severe seborrhea and/or seborrheic dermatitis on scalp. Scales and sebum of the scalp were seeded in the middle of modified Dixon and incubated at 32 degrees C. For genotypic identification polymerase chain reaction primers for the ITS and D1/D2 ribossomal DNA were used and followed by samples sequencing. The procedure was conducted before and after therapeutic and randomized intervention for moderate to severe seborrhea/seborrheic dermatitis on the scalp, including oral isotretinoin, 10 mg, every other day and anti-seborrheic shampoo (piroctone olamine), over six months. The M. globosa and M. restricta were the most frequent species isolated on the scalp before and after both treatments. Other non-Malassezia species were also identified. The Malassezia spp. were maintained in the scalp after both treatments that were equally effective for the control of seborrhea/seborrheic dermatitis clinical signs.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Med, Special Mycol Lab, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Med, Special Mycol Lab, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research Foundation [FAPESP]), Brazil
dc.description.sponsorshipIDFAPESP: 2010/51049-1
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1080/19381980.2017.1361573
dc.identifier.citationDermato-Endocrinology. Philadelphia, v. 9, n. 1, p. -, 2017.
dc.identifier.doi10.1080/19381980.2017.1361573
dc.identifier.fileWOS000428316900001.pdf
dc.identifier.issn1938-1972
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57132
dc.identifier.wosWOS:000428316900001
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofDermato-Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMalasseziaen
dc.subjectoral isotretinoinen
dc.subjectpiroctone olamineen
dc.subjectpolymerase chain reactionen
dc.subjectseborrheic dermatitisen
dc.titleCutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trialen
dc.typeinfo:eu-repo/semantics/article
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