Hypertriglyceridemic Waist Phenotype Indicates Insulin Resistance in Adolescents According to the Clamp Technique in the BRAMS Study

dc.contributor.authorBarreiro-Ribeiro, Francieli
dc.contributor.authorJunqueira Vasques, Ana Carolina
dc.contributor.authorda Silva, Cleliani de Cassia
dc.contributor.authorZambon, Mariana Porto
dc.contributor.authorDe Bernardi Rodrigues, Ana Maria
dc.contributor.authorCamilo, Daniella Fernandes
dc.contributor.authorde Goes Monteiro Antonio, Maria Angela Reis
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.authorda Silveira Campos, Raquel Munhoz
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorGeloneze, Bruno
dc.coverageNew Rochelle
dc.description.abstractObjective: This study aimed to identify cutoff points for detecting hypertriglyceridemic waist phenotype (HTWP) in adolescents and to investigate the association of the HTWP with insulin resistance (IR) and metabolic syndrome components. Methods: A multicentric cross-sectional study of 861 adolescents (10-19 years of age, 504 girls) was conducted. Pubertal stage, anthropometric, and laboratory parameters were assessed. IR was assessed by Homeostasis Model Assessment for Insulin Resistance (HOMA1-IR) index and hyperglycemic clamp (n = 80). HTWP was defined by the presence of increased plasma triglycerides (TGs) and increased waist circumference (WC) according to cutoff points obtained in ROC curve analysis given the HOMA1-IR index as a reference method. Results: Cutoffs for WC and TGs, with a higher sum of sensitivity (S) and specificity (E), were, respectively: >84cm (S:65.1%, E:71.9%) and >87mg/dL (S:65.1%, E:73.4%) in pubertal girlsen
dc.description.abstract>88.5cm (S:80.2%, E:60.2%) and >78mg/dL (S:60.5%, E:53.2%) in postpubertal girlsen
dc.description.abstract>94cm (S:73.1%, E:83.1%) and >79mg/dL (S:61.5%, E:60.2%) in pubertal boysen
dc.description.abstractand >99cm (S:81.3%, E:78.7%) and >86mg/dL in postpubertal boys (S:68.1%, E:60.7%). HTWP frequency was 27.5%. In the phenotype presence, after adjustment for age and pubertal stage, blood pressure and fasting glucose levels were elevated and high-density lipoprotein cholesterol was lower (p<0.001). Adolescents with the HTWP showed more IR, evaluated both by the HOMA1-IR and by the clamp test (p<0.003). Conclusion: The findings suggest HTWP as an IR status in adolescents. Cutoff point standardization for gender and pubertal stage, combined with the ease of application of the method, may allow their use for screening adolescents who would most benefit from lifestyle changes.en
dc.description.affiliationUniv Campinas UNICAMP, LIMED Lab Invest Metab & Diabet, Gastroctr, Campinas, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Sch Med Sci, Post Grad Program Child & Adolescent Hlth, Campinas, SP, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Sch Appl Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Post Grad Program Nutr, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, Dept Physiotherapy, Therapeut Resources Lab, Sao Carlos, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespPost-Graduate Program in Nutrition, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCNPq: 563664/2010-0
dc.description.sponsorshipIDCAPES: 01-P-4346-2015
dc.identifier.citationChildhood Obesity. New Rochelle, v. 12, n. 6, p. 446-454, 2016.
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofChildhood Obesity
dc.rightsAcesso restrito
dc.titleHypertriglyceridemic Waist Phenotype Indicates Insulin Resistance in Adolescents According to the Clamp Technique in the BRAMS Studyen