Sleep pattern and spectral analysis of caregiver-mothers of sons with Duchenne muscular dystrophy, and an examination of differences between carriers and non-carriers

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dc.citation.volume32
dc.contributor.authorNozoe, Karen Tieme [UNIFESP]
dc.contributor.authorKim, Lenise Jihe [UNIFESP]
dc.contributor.authorPolesel, Daniel Ninello [UNIFESP]
dc.contributor.authorHirotsu, Camila [UNIFESP]
dc.contributor.authorde Souza, Altay Lino [UNIFESP]
dc.contributor.authorHachul, Helena [UNIFESP]
dc.contributor.authorTufik, Sergio Brasil [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorMoreira, Gustavo Antonio [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-17T14:02:26Z
dc.date.available2020-07-17T14:02:26Z
dc.date.issued2017
dc.description.abstractObjectives: Sleep is essential for physical and mental well-being. However, poor sleep is a common complaint among caregivers. The aim of the present study was to determine sleep patterns of caregiver-mothers (CM group) of sons with Duchenne muscular dystrophy (DMD) and also to examine the differences between non-carriers and carriers of the gene related to DMD within the CM group. Methods: Observational case-control study. Participants: The CM and control (CTRL) groups were matched for age, body mass index and social class. Polysomnography was conducted in a sleep laboratory for one night. The discrete fast Fourier transformation method was used to calculate the electroencephalogram (EEG) power spectrum for the entire night and sleep stages. Results: The CM group presented higher sleep latency and N3 sleep stage compared with the CTRL. When carrier and non-carrier CM subgroups were analyzed, increased sleep latency and time awake, as well as reduced sleep efficiency and N2, were observed in the carrier group. Regarding respiratory parameters, carriers demonstrated higher hypopnea index values compared with non-carriers. Spectral analysis showed that carriers compared with non-carrier DMD caregiver-mothers presented lower spectral power in fast waves, mainly beta, during REM sleep in some EEG derivations. Conclusions: There was an impairment of sleep pattern in the CM group compared with CTRL mothersen
dc.description.abstractthis was possibly associated with difficulty in initiating sleep. Being a DMD gene carrying caregiver further compromised some aspects of sleep microstructure during REM sleep. The data demonstrated the importance of sleep evaluation in caregiver-mothers, and the relationship between sleep and being a carrier of the gene associated with DMD, which was demonstrated as possibly impacting sleep quality. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.affiliationCasa Saude Santa Marcelina, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2014/08067-0, 2015/19136-5]
dc.description.sponsorshipCNPq
dc.format.extent114-121
dc.identifierhttp://dx.doi.org/10.1016/j.sleep.2016.11.020
dc.identifier.citationSleep Medicine. Amsterdam, v. 32, p. 114-121, 2017.
dc.identifier.doi10.1016/j.sleep.2016.11.020
dc.identifier.issn1389-9457
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54810
dc.identifier.wosWOS:000400211300018
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofSleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCaregiveren
dc.subjectMotheren
dc.subjectDuchenne muscular dystrophyen
dc.subjectCarrieren
dc.subjectSleepen
dc.titleSleep pattern and spectral analysis of caregiver-mothers of sons with Duchenne muscular dystrophy, and an examination of differences between carriers and non-carriersen
dc.typeinfo:eu-repo/semantics/article
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