Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence

dc.contributor.authorMessas, G.
dc.contributor.authorMeira-Lima, I
dc.contributor.authorTurchi, M.
dc.contributor.authorFranco, O.
dc.contributor.authorGuindalini, C.
dc.contributor.authorCastelo, A.
dc.contributor.authorLaranjeira, R.
dc.contributor.authorVallada, H.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:38:03Z
dc.date.available2016-01-24T12:38:03Z
dc.date.issued2005-09-01
dc.description.abstractGenetic factors play a role in the vulnerability to cocaine dependence. the reinforcing properties of cocaine are related to the dopaminergic system, and, in particular, the dopamine receptors have been linked to the reward mechanisms. the present study examines the role of the variants Taql A of the dopamine D2 receptor gene and Ball of the dopamine D3 receptor gene in a Brazilian sample consisting of 730 cocaine dependents and 782 healthy controls. the studied polymorphisms did not show any difference in allelic frequencies or genotypic distribution between the groups. Our data do not support a role for the dopamine D2 receptor gene Taql A and dopamine D3 receptor gene Ball gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample.en
dc.description.affiliationUniv São Paulo, Sch Med, Neurosci Lab, Dept Psychiat,LIM 27, BR-05403010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, Unit Durg & Alcohol Res, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, Unit Durg & Alcohol Res, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent171-174
dc.identifierhttp://dx.doi.org/10.1097/00041444-200509000-00006
dc.identifier.citationPsychiatric Genetics. Philadelphia: Lippincott Williams & Wilkins, v. 15, n. 3, p. 171-174, 2005.
dc.identifier.doi10.1097/00041444-200509000-00006
dc.identifier.issn0955-8829
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28462
dc.identifier.wosWOS:000231808400005
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPsychiatric Genetics
dc.rightsAcesso restrito
dc.subjectgeneticsen
dc.subjectdopamine receptoren
dc.subjectaddictionen
dc.subjectgene polymorphismen
dc.titleAssociation study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependenceen
dc.typeArtigo
Arquivos