Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae)
dc.contributor.author | Campos, Jaqueline Ferreira | |
dc.contributor.author | Santos, Uilson Pereira dos | |
dc.contributor.author | Benitez Macorini, Luis Fernando | |
dc.contributor.author | Mestriner Felipe de Melo, Adriana Mary | |
dc.contributor.author | Perrella Balestieri, Jose Benedito | |
dc.contributor.author | Paredes-Gamero, Edgar Julian [UNIFESP] | |
dc.contributor.author | Lima Cardoso, Claudia Andrea | |
dc.contributor.author | Souza, Kely de Picoli | |
dc.contributor.author | Santos, Edson Lucas dos | |
dc.contributor.institution | Fed Univ Grande Dourados | |
dc.contributor.institution | Univ Ctr Grande Dourados | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Universidade Estadual de Mato Grosso do Sul (UEMS) | |
dc.date.accessioned | 2016-01-24T14:35:22Z | |
dc.date.available | 2016-01-24T14:35:22Z | |
dc.date.issued | 2014-03-01 | |
dc.description.abstract | Propolis from stingless bees is well known for its biologic properties; however, few studies have demonstrated these effects. Therefore, this study aimed to investigate the chemical composition and antimicrobial, antioxidant and cytotoxic activities of propolis from the stingless bee Melipona orbignyi, found in Mato Grosso do Sul, Brazil. the chemical composition of the ethanol extract of propolis (EEP) indicated the presence of aromatic acids, phenolic compounds, alcohols, terpenes and sugars. the EEP was active against the bacterium Staphylococcus aureus and the fungus Candida albicans. the EEP showed antioxidant activity by scavenging free radicals and inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated with an oxidizing agent. Additionally, EEP promoted cytotoxic activity and primarily necrotic death in K562 erythroleukemia cells. Taken together, these results indicate that propolis from M. orbignyi has therapeutic potential for the treatment and/or prevention of diseases related to microorganism activity, oxidative stress and tumor cell proliferation. (C) 2014 Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | Fed Univ Grande Dourados, Sch Environm & Biol Sci, BR-79804970 Dourados, MS, Brazil | |
dc.description.affiliation | Univ Ctr Grande Dourados, Dourados, MS, Brazil | |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil | |
dc.description.affiliation | Univ Estadual Mato Grosso do Sul, Course Chem, BR-79804970 Dourados, MS, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Development of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | FUNDECT | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipID | Development of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT: 23/200.729/2012 | |
dc.description.sponsorshipID | CNPq: 482661/2013-5 | |
dc.format.extent | 374-380 | |
dc.identifier | http://dx.doi.org/10.1016/j.fct.2014.01.008 | |
dc.identifier.citation | Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 65, p. 374-380, 2014. | |
dc.identifier.doi | 10.1016/j.fct.2014.01.008 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/37489 | |
dc.identifier.wos | WOS:000332500500045 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Food and Chemical Toxicology | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dc.subject | Stingless bee | en |
dc.subject | Oxidative stress | en |
dc.subject | Hemolysis | en |
dc.subject | Lipid peroxidation | en |
dc.subject | Necrosis | en |
dc.subject | Anti-tumor activity | en |
dc.title | Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae) | en |
dc.type | info:eu-repo/semantics/article |