Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae)

dc.contributor.authorCampos, Jaqueline Ferreira
dc.contributor.authorSantos, Uilson Pereira dos
dc.contributor.authorBenitez Macorini, Luis Fernando
dc.contributor.authorMestriner Felipe de Melo, Adriana Mary
dc.contributor.authorPerrella Balestieri, Jose Benedito
dc.contributor.authorParedes-Gamero, Edgar Julian [UNIFESP]
dc.contributor.authorLima Cardoso, Claudia Andrea
dc.contributor.authorSouza, Kely de Picoli
dc.contributor.authorSantos, Edson Lucas dos
dc.contributor.institutionFed Univ Grande Dourados
dc.contributor.institutionUniv Ctr Grande Dourados
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Mato Grosso do Sul (UEMS)
dc.date.accessioned2016-01-24T14:35:22Z
dc.date.available2016-01-24T14:35:22Z
dc.date.issued2014-03-01
dc.description.abstractPropolis from stingless bees is well known for its biologic properties; however, few studies have demonstrated these effects. Therefore, this study aimed to investigate the chemical composition and antimicrobial, antioxidant and cytotoxic activities of propolis from the stingless bee Melipona orbignyi, found in Mato Grosso do Sul, Brazil. the chemical composition of the ethanol extract of propolis (EEP) indicated the presence of aromatic acids, phenolic compounds, alcohols, terpenes and sugars. the EEP was active against the bacterium Staphylococcus aureus and the fungus Candida albicans. the EEP showed antioxidant activity by scavenging free radicals and inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated with an oxidizing agent. Additionally, EEP promoted cytotoxic activity and primarily necrotic death in K562 erythroleukemia cells. Taken together, these results indicate that propolis from M. orbignyi has therapeutic potential for the treatment and/or prevention of diseases related to microorganism activity, oxidative stress and tumor cell proliferation. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationFed Univ Grande Dourados, Sch Environm & Biol Sci, BR-79804970 Dourados, MS, Brazil
dc.description.affiliationUniv Ctr Grande Dourados, Dourados, MS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Estadual Mato Grosso do Sul, Course Chem, BR-79804970 Dourados, MS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipDevelopment of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFUNDECT
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDDevelopment of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT: 23/200.729/2012
dc.description.sponsorshipIDCNPq: 482661/2013-5
dc.format.extent374-380
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2014.01.008
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 65, p. 374-380, 2014.
dc.identifier.doi10.1016/j.fct.2014.01.008
dc.identifier.issn0278-6915
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37489
dc.identifier.wosWOS:000332500500045
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood and Chemical Toxicology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectStingless beeen
dc.subjectOxidative stressen
dc.subjectHemolysisen
dc.subjectLipid peroxidationen
dc.subjectNecrosisen
dc.subjectAnti-tumor activityen
dc.titleAntimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae)en
dc.typeinfo:eu-repo/semantics/article
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