Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells (vol 9, 2018)

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dc.citation.volumev. 9
dc.contributor.authorCaires-Junior, Luiz Carlos
dc.contributor.authorGoulart, Ernesto
dc.contributor.authorMelo, Uira Souto
dc.contributor.authorAraujo, Bruno Henrique Silva [UNIFESP]
dc.contributor.authorAlvizi, Lucas
dc.contributor.authorSoares-Schanoski, Alessandra
dc.contributor.authorOliveira, Danyllo Felipe de
dc.contributor.authorKobayashi, Gerson Shigeru
dc.contributor.authorGriesi-Oliveira, Karina
dc.contributor.authorMusso, Camila Manso
dc.contributor.authorAmaral, Murilo Sena
dc.contributor.authorSilva, Lucas Ferreira da
dc.contributor.authorAstray, Renato Mancini
dc.contributor.authorSuarez-Patino, Sandra Fernanda
dc.contributor.authorVentini, Daniella Cristina
dc.contributor.authorSilva, Sergio Gomes da
dc.contributor.authorYamamoto, Guilherme Lopes
dc.contributor.authorEzquina, Suzana
dc.contributor.authorNaslavsky, Michel Satya
dc.contributor.authorTelles-Silva, Kayque Alves
dc.contributor.authorWeinmann, Karina
dc.contributor.authorvan der Linden, Vanessa
dc.contributor.authorvan der Linden, Helio
dc.contributor.authorOliveira, Joao Ricardo Mendes de
dc.contributor.authorArrais, Nivia Maria Rodrigues
dc.contributor.authorMelo, Adriana
dc.contributor.authorFigueiredo, Thalita
dc.contributor.authorSantos, Silvana
dc.contributor.authorMeira, Joanna Goes Castro
dc.contributor.authorPassos, Saulo Duarte
dc.contributor.authorAlmeida, Roque Pacheco de
dc.contributor.authorBispo, Ana Jovina Barreto
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorKalil, Jorge
dc.contributor.authorCunha-Neto, Edecio
dc.contributor.authorNakaya, Helder
dc.contributor.authorAndreata-Santos, Robert
dc.contributor.authorFerreira, Luis Carlos de Souza
dc.contributor.authorVerjovski-Almeida, Sergio
dc.contributor.authorHo, Paulo Lee
dc.contributor.authorPassos-Bueno, Maria Rita
dc.contributor.authorZatz, Mayana
dc.coverageLondon
dc.date.accessioned2020-07-20T16:31:15Z
dc.date.available2020-07-20T16:31:15Z
dc.date.issued2018
dc.description.abstractCongenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS unaffected twins. Prior to Zika virus (ZIKV) infection the NPCs from CZS babies show a significantly different gene expression signature of mTOR and Wnt pathway regulators, key to a neurodevelopmental program. Following ZIKV in vitro infection, cells from affected individuals have significantly higher ZIKV replication and reduced cell growth. Whole-exome analysis in 18 affected CZS babies as compared to 5 unaffected twins and 609 controls excludes a monogenic model to explain resistance or increased susceptibility to CZS development. Overall, our results indicate that CZS is not a stochastic event and depends on NPC intrinsic susceptibility, possibly related to oligogenic and/or epigenetic mechanisms.en
dc.description.affiliationUniv Sao Paulo, Biosci Inst, Human Genome & Stem Cell Res Ctr, Dept Genet & Evolutionary Biol, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationBrazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, EPM, Dept Neurol & Neurosurg, Neurosci Lab, BR-04039002 Sao Paulo, SP, Brazil
dc.description.affiliationButantan Inst, BR-05503900 Sao Paulo, SP, Brazil
dc.description.affiliationAlbert Einstein Hosp, BR-05652900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Chem, Dept Biochem, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Mogi das Cruzes, BR-08780911 Mogi Das Cruzes, SP, Brazil
dc.description.affiliationAACD, BR-50080810 Recife, PE, Brazil
dc.description.affiliationRehabil Ctr Dr Henrique Santillo, BR-74653230 Goiania, Go, Brazil
dc.description.affiliationFed Univ Pernambuco UFPE, Neuropsychiat Dept, BR-50670901 Recife, PE, Brazil
dc.description.affiliationFed Univ Pernambuco UFPE, KeizoAsami Lab, BR-50670901 Recife, PE, Brazil
dc.description.affiliationFed Univ Rio Grande do Norte UFRN, Dept Pediat, BR-59010180 Natal, RN, Brazil
dc.description.affiliationISEA, BR-58400220 Campina Grande, PB, Brazil
dc.description.affiliationParaiba State Univ UEPB, Dept Biol, BR-58429500 Campina Grande, PB, Brazil
dc.description.affiliationFed Univ Bahia UFBA, BR-40170115 Salvador, BA, Brazil
dc.description.affiliationMed Sch Jundiai, Infect Pediat Lab, BR-40170115 Jundiai, SP, Brazil
dc.description.affiliationFed Univ Sergipe UFS, Div Immunol, BR-49100000 Aracaju, SP, Brazil
dc.description.affiliationFed Univ Sergipe UFS, Mol Biol Lab, BR-49100000 Aracaju, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Heart Inst, BR-05403900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Microbiol, Vaccine Dev Lab, BR-05508900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, EPM, Dept Neurol & Neurosurg, Neurosci Lab, BR-04039002 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES
dc.description.sponsorshipDECIT-MS
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1038/s41467-017-02790-9
dc.identifier.citationNature Communications. London, v. 9, 2018.
dc.identifier.doi10.1038/s41467-017-02790-9
dc.identifier.fileWOS000427248800003a.pdf
dc.identifier.issn2041-1723
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55823
dc.identifier.wosWOS:000427248800003a
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofNature Communications
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleDiscordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells (vol 9, 2018)en
dc.typeinfo:eu-repo/semantics/article
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