Underlying mechanism of portal hypertensive gastropathy in cirrhosis: A hemodynamic and morphological approach

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dc.contributor.authorCurvelo, Lilian Amorim [UNIFESP]
dc.contributor.authorBrabosa, Walnei [UNIFESP]
dc.contributor.authorRhor, Rachel [UNIFESP]
dc.contributor.authorLanzoni, Valeria [UNIFESP]
dc.contributor.authorParise, Edison Roberto [UNIFESP]
dc.contributor.authorFerrari, Angelo Paulo [UNIFESP]
dc.contributor.authorKondo, Mario [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:44Z
dc.date.available2016-01-24T13:58:44Z
dc.date.issued2009-09-01
dc.description.abstractBackground and Aim:Portal hypertensive gastropathy (PHG) is an important cause of bleeding in patients with cirrhosis associated with portal hypertension. Histologically, the condition is characterized by dilation of the mucosal and submucosal vessels of the stomach; however, its mechanisms remain unclear. the aim of the present cross-sectional study was to evaluate the role of portal and systemic hemodynamic features, humoral factors and hepatocellular function in the development and severity of PHG in patients with cirrhosis.Methods:Forty-six patients with cirrhosis of different etiologies underwent endoscopy. Portal hypertension was evaluated by hepatic venous pressure gradient (HVPG). the gastric mucosa was analyzed using two diagnostic methods: endoscopy according to the McCormack criteria and histological by histomorphometric analysis.Results:The prevalence of PHG according to the endoscopic and histomorphometric methods was 93.4% and 76.1%, respectively. There were no statistically significant differences in HVPG measurements between the patients with mild (16.0 +/- 5.9 mmHg) and severe PHG (16.9 +/- 6.5 mmHg; P = 0.80) or between patients who did not have (15.2 +/- 8.0 mmHg) and those who had PHG (16.3 +/- 5.7 mmHg). No correlation was found between the presence or severity of PHG and systemic vascular resistance index (P = 0.53 and 0.34, respectively), Child-Pugh classification (P = 0.73 and 0.78, respectively) or glucagon levels (P = 0.59 and 0.62, respectively).Conclusions:The present data show no correlation between the presence or the severity of PHG and portal pressure, Child-Pugh classification or systemic hemodynamics, suggesting that other factors may be involved in the physiopathology of PHG, such as local gastric mucosal factors or other underlying factors.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Gastroenterol & Hepatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Gastroenterol & Hepatol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1541-1546
dc.identifierhttp://dx.doi.org/10.1111/j.1440-1746.2009.05871.x
dc.identifier.citationJournal of Gastroenterology and Hepatology. Malden: Wiley-Blackwell Publishing, Inc, v. 24, n. 9, p. 1541-1546, 2009.
dc.identifier.doi10.1111/j.1440-1746.2009.05871.x
dc.identifier.issn0815-9319
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31802
dc.identifier.wosWOS:000269582900013
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Gastroenterology and Hepatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectcirrhosisen
dc.subjecthepatocellular functionen
dc.subjectportal hemodynamicsen
dc.subjectportal hypertensionen
dc.subjectportal hypertensive gastropathyen
dc.titleUnderlying mechanism of portal hypertensive gastropathy in cirrhosis: A hemodynamic and morphological approachen
dc.typeinfo:eu-repo/semantics/article
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