The emerging role of mirnas and their clinical implication in biliary tract cancer

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dc.contributor.authorFerreira Martins, Nina Nayara
dc.contributor.authorda Silva Oliveira, Kelly Cristina
dc.contributor.authorBona, Amanda Braga
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.authorIshak, Geraldo
dc.contributor.authorAssumpcao, Paulo Pimentel
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorCalcagno, Danielle Queiroz
dc.date.accessioned2019-01-21T10:29:34Z
dc.date.available2019-01-21T10:29:34Z
dc.date.issued2016
dc.description.abstractBiliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra-and extrahepatic ducts and have a poor prognosis. Surgical resection remains themain curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several singlenucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.en
dc.description.affiliationNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil
dc.description.affiliationLaboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.identifierhttp://dx.doi.org/10.1155/2016/9797410
dc.identifier.citationGastroenterology Research And Practice. New york, 2016.
dc.identifier.doi10.1155/2016/9797410
dc.identifier.fileWOS000392001900001.pdf
dc.identifier.issn1687-6121
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49276
dc.identifier.wosWOS:000392001900001
dc.language.isoeng
dc.publisherEditora Unilasalle
dc.relation.ispartofGastroenterology Research And Practice
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIntrahepatic Cholangiocarcinoma Cellsen
dc.subjectNorth Indian Populationen
dc.subjectGallbladder Canceren
dc.subjectTumor-Suppressoren
dc.subjectGastric-Canceren
dc.subjectGenetic-Variantsen
dc.subjectMesenchymal Transitionen
dc.subjectEpigenetic Regulationen
dc.subjectDown-Regulationen
dc.subjectC-Mycen
dc.titleThe emerging role of mirnas and their clinical implication in biliary tract canceren
dc.typeinfo:eu-repo/semantics/review
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