WR2721 BONE-MARROW RADIOPROTECTION - LIGHT AND ELECTRON-MICROSCOPE STUDY

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dc.contributor.authorSegreto, Helena Regina Comodo [UNIFESP]
dc.contributor.authorSegreto, Roberto Araujo [UNIFESP]
dc.contributor.authorSilva, MRR
dc.contributor.authorEgami, Mizue Imoto [UNIFESP]
dc.contributor.authorGhiraldini, M.
dc.contributor.authorNovo, Neil Ferreira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:44:08Z
dc.date.available2018-06-15T17:44:08Z
dc.date.issued1995-07-01
dc.description.abstractTo assess the radioprotection afforded by the S- 2- (3 aminopropylamino) ethylphosphorotioic acid (WR2721), bone marrow obtained from mouse femora was examined by means of light and electron microscope 1, 3, 6 and 10 days after a single whole body X ray dose of 7 Gy.Comparing the protected to the unprotected bone marrows, the following features were observed in the protected ones: (1) less depletion of parenchyma cells; (2) less vascular dilatation and hyperemia in parenchyma; (3) apparently less apoptotic figures present 1 day after irradiation and (4) the recovery process occurred earlier.Despite the hyperemia in the parenchyma during the injury phase, the continuity of the sinus wall was maintained in the protected and unprotected marrows.The morphometric method used (NN/N ratio) allowed the estimation of the WR2721 bone marrow radioprotection through the relation of vascular stroma and cellular parenchyma.en
dc.description.affiliationESCOLA PAULISTA MED,DEPT PATHOL,DIV APPL PATHOL,SAO PAULO,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,DEPT MORPHOL,DIV HISTOL,SAO PAULO,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,CTR ANIM,SAO PAULO,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,DEPT PREVENT MED,DIV BIOSTAT,SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT PATHOL,DIV APPL PATHOL,SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT MORPHOL,DIV HISTOL,SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,CTR ANIM,SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT PREVENT MED,DIV BIOSTAT,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent215-221
dc.identifier.citationInterciencia. Caracas: Interciencia, v. 20, n. 4, p. 215-221, 1995.
dc.identifier.issn0378-1844
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43981
dc.identifier.wosWOS:A1995RP57300007
dc.language.isoeng
dc.publisherInterciencia
dc.relation.ispartofInterciencia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectIONIZING RADIATIONen
dc.subjectRADIOPROTECTORen
dc.subjectACUTE EFFECTS ON BONE MARROWen
dc.titleWR2721 BONE-MARROW RADIOPROTECTION - LIGHT AND ELECTRON-MICROSCOPE STUDYen
dc.typeinfo:eu-repo/semantics/article
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