Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Disease

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dc.contributor.authorKohanim, Sahar
dc.contributor.authorPalioura, Sotiria
dc.contributor.authorSaeed, Hajirah N.
dc.contributor.authorAkpek, Esen K.
dc.contributor.authorAmescua, Guillermo
dc.contributor.authorBasu, Sayan
dc.contributor.authorBlomquist, Preston H.
dc.contributor.authorBouchard, Charles S.
dc.contributor.authorDart, John K.
dc.contributor.authorGai, Xiaowu
dc.contributor.authorGomes, José Álvaro Pereira [UNIFESP]
dc.contributor.authorGregory, Darren G.
dc.contributor.authorIyer, Geetha
dc.contributor.authorJacobs, Deborah S.
dc.contributor.authorJohnson, Anthony J.
dc.contributor.authorKinoshita, Shigeru
dc.contributor.authorMantagos, Iason S.
dc.contributor.authorMehta, Jodhbir S.
dc.contributor.authorPerez, Victor L.
dc.contributor.authorPflugfelder, Stephen C.
dc.contributor.authorSangwan, Virender S.
dc.contributor.authorSippel, Kimberly C.
dc.contributor.authorSotozono, Chie
dc.contributor.authorSrinivasan, Bhaskar
dc.contributor.authorTan, Donald T. H.
dc.contributor.authorTandon, Radhika
dc.contributor.authorTseng, Scheffer C. G.
dc.contributor.authorUeta, Mayumi
dc.contributor.authorChodosh, James
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-07-26T17:30:30Z
dc.date.available2018-07-26T17:30:30Z
dc.date.issued2016
dc.description.abstractThe intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TEN represent two ends of a spectrum of immune-mediated, dermatobullous disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. The widespread keratinocyte death seen in SJS/TEN is rapid and irreversible, and even with early and aggressive intervention, morbidity is severe and mortality not uncommon. We have divided this review into two parts. Part I summarizes the epidemiology and immunopathogenesis of SJS/TEN and discusses systemic therapy and its possible benefits. We hope this review will help the ophthalmologist better understand the mechanisms of disease in SJS/TEN and enhance their care of patients with this complex and often debilitating disease. Part II (April 2016 issue) will focus on ophthalmic manifestations.en
dc.description.affiliationVanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, TN 37212 USA
dc.description.affiliationBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136 USA
dc.description.affiliationMassachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114 USA
dc.description.affiliationJohns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA
dc.description.affiliationLV Prasad Eye Institute, Hyderabad, Andhra Pradesh, India
dc.description.affiliationUniversity of Texas Southwestern Medical Center, Dallas, TX 75390 USA
dc.description.affiliationLoyola University, Chicago, IL 60611 USA
dc.description.affiliationMoorfields Eye Hospital, NHS Foundation Trust, London, UK
dc.description.affiliationFederal University of São Paulo, Sao Paulo, Brazil
dc.description.affiliationRocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, CO USA
dc.description.affiliationDr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Sankara Nethralaya, India
dc.description.affiliationBoston Foundation for Sight, Boston, MA
dc.description.affiliationUnited States Army Institute of Surgical Research, San Antonio, TX USA
dc.description.affiliationKyoto Prefectural University of Medicine, Kyoto, Japan
dc.description.affiliationBoston Children's Hospital, Harvard Medical School, Boston, MA USA
dc.description.affiliationSingapore National Eye Centre, Singapore Eye Research Institute, Singapore
dc.description.affiliationCullen Eye Institute, Baylor College of Medicine, Houston, TX 77030 USA
dc.description.affiliationWeill Cornell Medical College, New York, NY USA
dc.description.affiliationAll India Inst Med Sci, Rajendra Prasad Ctr Ophthalm Sci, Delhi, India
dc.description.affiliationOcular Surface Center, Ocular Surface Research & Education Foundation, Miami, FL USA
dc.description.affiliationUnifespFederal University of São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipResearch to Prevent Blindness, NY, NY
dc.format.extent2-19
dc.identifierhttps://dx.doi.org/10.1016/j.jtos.2015.10.002
dc.identifier.citationOcular Surface. Amsterdam, v. 14, n. 1, p. 2-19, 2016.
dc.identifier.doi10.1016/j.jtos.2015.10.002
dc.identifier.issn1542-0124
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/46086
dc.identifier.wosWOS:000367241300002
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofOcular Surface
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectApoptosisen
dc.subjectDrug-induced diseaseen
dc.subjectImmune-mediated diseaseen
dc.subjectKeratinocyte death Stevens-Johnson Syndromeen
dc.subjectToxic epidermal necrolysisAdverse Drug-Reactionsen
dc.subjectColony-Stimulating Factoren
dc.subjectIntravenous Immunoglobulin Therapyen
dc.subjectOcular Surface Complicationsen
dc.subjectDexamethasone Pulse Therapyen
dc.subjectSevere Mucosal Involvementen
dc.subjectErythema Multiforme Majoren
dc.subjectNecrosis-Factor-Alphaen
dc.subjectCytotoxic T-Cellsen
dc.subjectOf-The-Literatureen
dc.titleStevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Diseaseen
dc.typeinfo:eu-repo/semantics/article
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