Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients

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dc.citation.issue2
dc.citation.volume9
dc.contributor.authordo Espirito Santo, Gilmar Ferreira [UNIFESP]
dc.contributor.authorGalera, Bianca Borsatto
dc.contributor.authorDuarte, Elisabeth Carmen
dc.contributor.authorChen, Elisabeth Suchi [UNIFESP]
dc.contributor.authorAzis, Lenuce
dc.contributor.authorDamazo, Amilcar Sabino
dc.contributor.authorSaba, Gabriela Tognini [UNIFESP]
dc.contributor.authorGehrke, Flavia de Sousa
dc.contributor.authorCotrim Guerreiro da Silva, Ismael Dale [UNIFESP]
dc.contributor.authorWaisberg, Jaques [UNIFESP]
dc.coveragePleasanton
dc.date.accessioned2020-07-17T14:02:57Z
dc.date.available2020-07-17T14:02:57Z
dc.date.issued2017
dc.description.abstractAIM To investigate the associations of the genetic polymorphisms of vascular endothelial growth factor A (VEGF-A) -1498C> T and -634G> C, with the survival of patients with colorectal cancer (CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction (PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A -1498C> T (rs833031) and -634G> C (rs2010963) polymorphisms. Genotyping was validated for VEGF-A -1498C> T polymorphism in 129 patients and for VEGF-A -634G> C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association (OR = 0.32en
dc.description.abstractP = 0.048) between genotype CC of the VEGF-A -1498C> T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A -1498C> T polymorphism and VEGF-A -634G> C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A -1498C> T polymorphism was significantly correlated with the 5-year survival (P = 0.032), but not significant difference (P = 0.27) was obtained with the VEGF-A -634G> C polymorphism with the 5-year survival in the univariate analysis. The genotype CT (HR = 2.79) and CC (HR = 4.67) of the polymorphism VEGF-A -1498C> T and the genotype CC (HR = 3.76) of the polymorphism VEGF-A -634C> G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A -1498C>T and the CC genotype of the VEGF-A -634C>G polymorphisms are prognostic factors of survival in Brazilians patients with sporadic colorectal carcinoma.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, Escola Paulista Med, Rua Napoleao de Barros 715, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Sch Med, Genet Lab Basics Hlth Sci Dept, BR-78060900 Cuiaba, Brazil
dc.description.affiliationBrasilia Univ, Sch Med, Trop Med Div, Campus Darcy Ribeiro Univ, BR-70904970 Brasilia, DF, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Genet Lab, Morphol & Genet Dept, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationABC Med Sch, Lab Clin Anal, Ave Principe Gales, BR-09060650 Santo Andre, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynecol, Lab Mol Gynecol, Rua Pedro de Toledo, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Surg, Escola Paulista Med, Rua Napoleao de Barros 715, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Genet Lab, Morphol & Genet Dept, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Gynecol, Lab Mol Gynecol, Rua Pedro de Toledo, BR-04039032 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent78-86
dc.identifierhttp://dx.doi.org/10.4251/wjgo.v9.i2.78
dc.identifier.citationWorld Journal Of Gastrointestinal Oncology. Pleasanton, v. 9, n. 2, p. 78-86, 2017.
dc.identifier.doi10.4251/wjgo.v9.i2.78
dc.identifier.fileWOS000400552700004.pdf
dc.identifier.issn1948-5204
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55098
dc.identifier.wosWOS:000400552700004
dc.language.isoeng
dc.publisherBaishideng Publishing Group Inc
dc.relation.ispartofWorld Journal Of Gastrointestinal Oncology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectColorectal canceren
dc.subjectGenetic polymorphismsen
dc.subjectVascular endothelial growth factor-Aen
dc.subjectColorectal surgeryen
dc.subjectGenetic variationen
dc.titlePrognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patientsen
dc.typeinfo:eu-repo/semantics/article
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