Cell death and regeneration in the midgut of the mosquito, Culex quinquefasciatus

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dc.contributor.authorOkuda, Kendi
dc.contributor.authorAlmeida, Fabio de
dc.contributor.authorMortara, Renato A.
dc.contributor.authorKrieger, Henrique
dc.contributor.authorMarinotti, Osvaldo
dc.contributor.authorBijovsky, A. Tania
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Calif Irvine
dc.date.accessioned2016-01-24T13:49:15Z
dc.date.available2016-01-24T13:49:15Z
dc.date.issued2007-12-01
dc.description.abstractHaematophagy, the utilization of blood as food, has evolved independently among insects such as mosquitoes, bedbugs, fleas, and others. Accordingly, several distinct biological adaptations have occurred in order to facilitate the finding, ingestion and digestion of blood from vertebrate sources. Although blood meals are essential for survival and reproduction of these insects, mechanical and chemical stresses are caused by the ingestion of a sizable meal (frequently twice or more times the weight of the insect) containing large amounts of cytotoxic molecules such as haem. Here we present data showing that the stresses caused by a blood meal induce cell death in the midgut epithelium of Culex quinquefasciatus mosquitoes. the process involves apoptosis, ejection of dead cells to the midgut lumen and differentiation of basal regenerative cells to replace the lost digestive cells. the basal cell differentiation in blood-fed mosquito midguts represents an additional mechanism by which insects cope with the stresses caused by blood meals. C quinquefasciatus adult females are unable to replace lost cells following a third or fourth blood meal, which may have a significant impact on mosquito longevity, reproduction and vectorial capacity. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1307-1315
dc.identifierhttp://dx.doi.org/10.1016/j.jinsphys.2007.07.005
dc.identifier.citationJournal of Insect Physiology. Oxford: Pergamon-Elsevier B.V., v. 53, n. 12, p. 1307-1315, 2007.
dc.identifier.doi10.1016/j.jinsphys.2007.07.005
dc.identifier.issn0022-1910
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30186
dc.identifier.wosWOS:000251333200012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Insect Physiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCulex quinquefusciatusen
dc.subjectmosquitoen
dc.subjectmidguten
dc.subjectapoptosisen
dc.subjectcell deathen
dc.subjectregenerative cellen
dc.subjectcell differentiationen
dc.subjectultrastructureen
dc.titleCell death and regeneration in the midgut of the mosquito, Culex quinquefasciatusen
dc.typeinfo:eu-repo/semantics/article
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