A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

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dc.contributor.authorLeake, Pierre-Anthony
dc.contributor.authorCardoso, Roberta
dc.contributor.authorSeevaratnam, Rajini
dc.contributor.authorLourenço, Laércio Gomes [UNIFESP]
dc.contributor.authorHelyer, Lucy
dc.contributor.authorMahar, Alyson
dc.contributor.authorRowsell, Corwyn
dc.contributor.authorCoburn, Natalie G.
dc.contributor.institutionUniv Toronto
dc.contributor.institutionSunnybrook Hlth Sci Ctr
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionDalhousie Univ
dc.contributor.institutionQueens Univ
dc.date.accessioned2016-01-24T14:27:37Z
dc.date.available2016-01-24T14:27:37Z
dc.date.issued2012-09-01
dc.description.abstractBackground There is lack of uniformity in the utilization of peritoneal cytology in gastric cancer management. the identification of intraperitoneal free cancer cells (IFCCs) is believed to confer poor prognosis. However, while some of these patients are palliated, others may undergo more aggressive therapies. in this review, we aimed to identify and synthesize findings on the use of peritoneal cytology in predicting peritoneal recurrence and overall survival in curative gastric cancer patients.Methods Electronic literature searches were conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 31, 2009. We determined the accuracy, sensitivity, and specificity of peritoneal cytology in predicting peritoneal recurrence based on four techniques-conventional cytology, immunoassay, immunohistochemistry, and reverse transcriptase-polymerase chain reaction. Recurrence rates and overall survival rates for curative patients were determined, based on positivity or negativity for IFCCs.Results Twenty-eight articles were included. All four techniques showed wide variations in accuracy, sensitivity, and specificity in predicting peritoneal recurrence. Recurrence rates for patients positive for IFCCs ranged from 11.1 to 100%, while those negative for IFCCs had recurrence rates of 0-51%. Overall survival was significantly reduced for patients with positive IFCCs. Short follow-up periods and possible duplication of results may limit result interpretation.Conclusion the presence of IFCCs appears to increase the risk of peritoneal recurrence and is associated with worse overall survival in gastric cancer patients. Further incorporation of peritoneal cytology in clinical decision-making in gastric cancer depends on the development of a consistently accurate and rapid IFCC detection method.en
dc.description.affiliationUniv Toronto, Dept Surg, Toronto, ON, Canada
dc.description.affiliationSunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationDalhousie Univ, Dept Surg, Halifax, NS B3H 4H2, Canada
dc.description.affiliationQueens Univ, Dept Community Hlth & Epidemiol, Kingston, ON, Canada
dc.description.affiliationSunnybrook Hlth Sci Ctr, Dept Anat Pathol, Toronto, ON M4N 3M5, Canada
dc.description.affiliationUniv Toronto, Div Surg Oncol, Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Toronto, ON, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCanadian Cancer Society
dc.description.sponsorshipOntario Ministry of Health and Long-Term Care
dc.description.sponsorshipIDCanadian Cancer Society: 019325
dc.format.extentS27-S37
dc.identifierhttp://dx.doi.org/10.1007/s10120-011-0071-z
dc.identifier.citationGastric Cancer. New York: Springer, v. 15, p. S27-S37, 2012.
dc.identifier.doi10.1007/s10120-011-0071-z
dc.identifier.issn1436-3291
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35209
dc.identifier.wosWOS:000313419000005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofGastric Cancer
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectGastric canceren
dc.subjectCytologyen
dc.subjectPeritoneal cavityen
dc.subjectRecurrenceen
dc.subjectSurvivalen
dc.titleA systematic review of the accuracy and utility of peritoneal cytology in patients with gastric canceren
dc.typeinfo:eu-repo/semantics/article
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