Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study

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dc.contributor.authorSaggioro, Fabiano Pinto
dc.contributor.authorNeder, Luciano
dc.contributor.authorStávale, João Norberto [UNIFESP]
dc.contributor.authorPaixão-Becker, Aline Nazareth de Paiva
dc.contributor.authorMalheiros, Suzana Maria Fleury [UNIFESP]
dc.contributor.authorSoares, Fernando Augusto
dc.contributor.authorPittella, José Eymard Homem
dc.contributor.authorMatias, Caio César Marconato Simões
dc.contributor.authorColli, Benedicto Oscar
dc.contributor.authorCarlotti Junior, Carlos Gilberto
dc.contributor.authorFranco, Marcello Fabiano de [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Canc AC Camargo
dc.date.accessioned2016-01-24T14:34:54Z
dc.date.available2016-01-24T14:34:54Z
dc.date.issued2014-01-01
dc.description.abstractThis investigation analyzed the immunoexpression of FasL, Fas, cleaved caspase-8, and cleaved caspase-3 in glioblastomas. Formalin-fixed and paraffin-embedded glioblastoma tissues and control brain tissues from 97 patients were analyzed by tissue microarrays and immunohistochemistry. Patients with glioblastomas that were negative or weakly stained (<50% of cells positive) for cleaved caspase-8 had worse cancer-specific overall survival (median=8.5 months) than did patients with tumors that highly expressed cleaved caspase-8 (median=11.7 months; P=0.0325), independent of clinical variables. There was no association of other markers with survival, treatment, sex, age, tumor size, and primary site. Among the tumors, there were reasonable to good positive correlations between the expression of FasL and Fas (r=0.47) and between Fas and cleaved caspase-8 (r=0.41), and there were poor positive correlations between Fas and cleaved caspase-3 (r=0.26), FasL and cleaved caspase-8 (r=0.22), and cleaved caspase-8 and -3 (r=0.31). Our results suggest that Fas-Fas-ligand signal transduction could be inhibited, especially at the stage of caspase-8 activation, thereby establishing a major mechanism for evasion of apoptosis by these tumors. the absence or low expression of cleaved caspase-8 in the tumors was a negative prognostic indicator for patient survival. (C) 2014 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniv São Paulo FMRR USP, Fac Med Ribeirao Preto, Dept Pathol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP EPM, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP EPM, Dept Neurol, São Paulo, Brazil
dc.description.affiliationHosp Canc AC Camargo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Surg, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP EPM, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP EPM, Dept Neurol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 04/09932-4
dc.format.extent267-273
dc.identifierhttp://dx.doi.org/10.1016/j.prp.2013.12.012
dc.identifier.citationPathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 210, n. 5, p. 267-273, 2014.
dc.identifier.doi10.1016/j.prp.2013.12.012
dc.identifier.fileWOS000335206600001.pdf
dc.identifier.issn0344-0338
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37117
dc.identifier.wosWOS:000335206600001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPathology Research and Practice
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectGlioblastomaen
dc.subjectCleaved caspase 8en
dc.subjectApoptosisen
dc.subjectSurvivalen
dc.subjectCaspase 3en
dc.titleFas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based studyen
dc.typeinfo:eu-repo/semantics/article
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