Thin minimal rim width at Bruch's membrane opening is associated with glaucomatous paracentral visual field loss

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dc.citation.volume11
dc.contributor.authorTaniguchi, Elise V. [UNIFESP]
dc.contributor.authorPaschalis, Eleftherios I.
dc.contributor.authorLi, Dejiao
dc.contributor.authorNouri-Mahdavi, Kouros
dc.contributor.authorBrauner, Stacey C.
dc.contributor.authorGreenstein, Scott H.
dc.contributor.authorTuralba, Angela V.
dc.contributor.authorWiggs, Janey L.
dc.contributor.authorPasquale, Louis R.
dc.contributor.authorShen, Lucy Q.
dc.coverageAlbany
dc.date.accessioned2020-07-17T14:03:24Z
dc.date.available2020-07-17T14:03:24Z
dc.date.issued2017
dc.description.abstractPurpose: To compare optic nerve head (ONH) measurements in glaucomatous eyes with paracentral visual field (VF) loss to eyes with peripheral VF loss and controls. Methods: Open-angle glaucoma (OAG) patients with early paracentral VF loss or isolated peripheral VF loss as well as control subjects underwent ONH imaging with swept-source optical coherence tomography (OCT) and retinal nerve fiber layer (RNFL) imaging with spectral-domain OCT. Minimum rim width at Bruch's membrane opening (BMO-MRW), lamina cribrosa depth (LCD), and RNFL thickness were compared among the glaucoma and control groups with one-way analysis of variance, Kruskal-Wallis test, and multiple regression analysis. Results: Twenty-nine eyes from 29 OAG patients (15 early paracentral and 14 isolated peripheral VF loss) and 20 eyes of 20 control subjects were included. The early paracentral and isolated peripheral VF loss groups had similar VF mean deviation (MD) (-5.3 +/- 2.7 dB and -3.7 +/- 3.0 dB, p=0.15, respectively). Global BMO-MRW was lower in OAG eyes than in controls (193.8 +/- 40.0 vs 322.7 +/- 62.2 mu m, p<0.001), but similar between eyes with early paracentral VF loss and those with isolated peripheral VF loss (187.6 +/- 43.4 vs 200.6 +/- 36.3 mu men
dc.description.abstractp>0.99). In contrast, the minimal BMO-MRW was lower in eyes with early paracentral loss (69.0 +/- 33.6 mu m) than in eyes with isolated peripheral loss (107.7 +/- 40.2 mu men
dc.description.abstractp=0.03) or control eyes (200.1 +/- 40.8 mu men
dc.description.abstractp<0.001). Average and thinnest RNFL thickness did not differ between OAG groups (p=0.61 and 0.19, respectively). Horizontal and vertical LCD did not differ among the OAG groups and controls (p=0.80 and 0.82, respectively). Multivariable linear regression analysis among OAG cases confirmed the association between lower minimal BMO-MRW and early paracentral VF loss (beta=-38.3 mu men
dc.description.abstract95% confidence interval, -69.8 to -6.8 mu men
dc.description.abstractp=0.02) after adjusting for age, gender, MD, and disc size. Conclusion: Thin minimal BMO-MRW may represent a new structural biomarker associated with early glaucomatous paracentral VF loss.en
dc.description.affiliationHarvard Med Sch, Dept Ophthalmol, Massachusetts Eye & Ear, 243 Charles St, Boston, MA 02114 USA
dc.description.affiliationHarvard Med Sch, Schepens Eye Res Inst, Boston Keratoprosthesis Lab, Massachusetts Eye & Ear, Boston, MA USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationBeijing China Japan Friendship Hosp, Dept Ophthalmol, Beijing, Peoples R China
dc.description.affiliationDavid Geffen Sch Med, Dept Ophthalmol, Los Angeles, CA USA
dc.description.affiliationStein Eye Inst, Los Angeles, CA USA
dc.description.affiliationHarvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipHarvard Glaucoma Center of Excellence
dc.description.sponsorshipMiller Research Funds at the Massachusetts Eye and Ear
dc.format.extent2157-2167
dc.identifierhttp://dx.doi.org/10.2147/OPTH.S149300
dc.identifier.citationClinical Ophthalmology. Albany, v. 11, p. 2157-2167, 2017.
dc.identifier.doi10.2147/OPTH.S149300
dc.identifier.fileWOS000417715800001.pdf
dc.identifier.issn1177-5483
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55374
dc.identifier.wosWOS:000417715800001
dc.language.isoeng
dc.publisherDove Medical Press Ltd
dc.relation.ispartofClinical Ophthalmology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectparacentral lossen
dc.subjectBMO-MRWen
dc.subjectopen angle glaucomaen
dc.subjectoptic nerve damageen
dc.subjectswept-source OCTen
dc.titleThin minimal rim width at Bruch's membrane opening is associated with glaucomatous paracentral visual field lossen
dc.typeinfo:eu-repo/semantics/article
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