Effect of the consumption of green tea extract during pregnancy and lactation on metabolism of mothers and 28d-old offspring

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dc.citation.volume8
dc.contributor.authorLosinskas Hachul, Ana Claudia [UNIFESP]
dc.contributor.authorBoldarine, Valter Tadeu [UNIFESP]
dc.contributor.authorPinto Neto, Nelson Inacio [UNIFESP]
dc.contributor.authorMoreno, Mayara Franzoi [UNIFESP]
dc.contributor.authorCarvalho, Patricia Oliveira
dc.contributor.authorSawaya, Alexandra C. H. F.
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorOiler do Nascimento, Claudia Maria [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-08T13:09:51Z
dc.date.available2020-07-08T13:09:51Z
dc.date.issued2018
dc.description.abstractThe objective was to investigate the effects of the maternal consumption of the green tea extract during pregnancy and lactation on mothers and offspring metabolism. The female Wistar rats, on the first day of pregnancy until the end of lactation, was divided into groups: MC-received water and ME-received green tea extract (400 mg/kg body weight/day), both ingested control diet. After lactation, at day 28th post-partum, the mothers and pups from each mother were euthanized and composed the groups: FC-pup from mother received water and FE-pup from mother received green tea extract. The ME group increased IL-10/TNF-alpha ratio and IL-1 beta content in the mesenteric and IL-1 beta content in retroperitoneal adipose tissues, and decreased catalase activity. The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues. In summary, the maternal consumption of green tea extract associated with control diet ingestion during pregnancy and lactation altered the inflammatory status of mothers and 28d-old offspring. These data elucidate the effects of green tea during pregnancy and lactation on maternal and offspring metabolism.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Francisco, Lab Multidisciplinary Res, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Plant Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico, Tecnologico (CNPq)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipCNPq fellowships
dc.description.sponsorshipIDFAPESP: 2014/19508-7
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1038/s41598-018-20174-x
dc.identifier.citationScientific Reports. London, v. 8, p. -, 2018.
dc.identifier.doi10.1038/s41598-018-20174-x
dc.identifier.fileWOS000423508900040.pdf
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54246
dc.identifier.wosWOS:000423508900040
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEffect of the consumption of green tea extract during pregnancy and lactation on metabolism of mothers and 28d-old offspringen
dc.typeinfo:eu-repo/semantics/article
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