B-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory properties

Página do item simplificado
dc.contributor.authorLopes, Jose Daniel [UNIFESP]
dc.contributor.authorMariano, Mario [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T13:50:09Z
dc.date.available2018-06-15T13:50:09Z
dc.date.issued2009-09-01
dc.description.abstractCharacterization of the origin, properties, functions and fate of cells is a fundamental task for the understanding of physiological and pathological phenomena. Despite the bulk of knowledge concerning the diverse characteristics of mammalian cells, some of them, such as B-1 cells, are still poorly understood. Here we report the results obtained in our laboratory on these cells in the last 10 years. After showing that B-1 cells could be cultured and amplified in vitro, a series of experiments were performed with these cells. They showed that B1 cells reside mostly in the peritoneal and pleural cavities, migrate to distant inflammatory foci, coalesce to form giant cells and participate in granuloma formation, both in vitro and in vivo. They are also able to present antigens to immunologically responsive cells and are endowed with regulatory properties. Further, we have also shown that these cells facilitate different types of infection as well as tumor growth and spreading. These data are presently reviewed pointing to a pivotal role that these cells may play in innate and acquired immunity.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 07/51501-9
dc.description.sponsorshipIDFAPESP: 04/08506-1
dc.format.extent489-496
dc.identifierhttp://dx.doi.org/10.1590/S0001-37652009000300013
dc.identifier.citationAnais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 81, n. 3, p. 489-496, 2009.
dc.identifier.doi10.1590/S0001-37652009000300013
dc.identifier.fileS0001-37652009000300013.pdf
dc.identifier.issn0001-3765
dc.identifier.scieloS0001-37652009000300013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42526
dc.identifier.wosWOS:000269462300013
dc.language.isoeng
dc.publisherAcad Brasileira De Ciencias
dc.relation.ispartofAnais Da Academia Brasileira De Ciencias
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectB-1 cellsen
dc.subjectIL-10en
dc.subjectinflammationen
dc.subjectinfectionen
dc.subjectneoplasiaen
dc.subjectBALB/Xid miceen
dc.titleB-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory propertiesen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos