Inactivation of muscarinic receptors impairs place and response learning: Implications for multiple memory systems

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dc.contributor.authorKramer Soares, Juliana Carlota [UNIFESP]
dc.contributor.authorMenezes Oliveira, Maria Gabriela [UNIFESP]
dc.contributor.authorFerreira, Tatiana Lima [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2016-01-24T14:34:32Z
dc.date.available2016-01-24T14:34:32Z
dc.date.issued2013-10-01
dc.description.abstractExtensive research has shown that the hippocampus and striatum have dissociable roles in memory and are necessary for place and response learning, respectively. Additional evidence indicates that muscarinic cholinergic receptors in the hippocampus and striatum exert an important role in the modulation of these memory systems. in our experiments, we assessed whether intact hippocampal and striatal muscarinic cholinergic transmission may be essential and/or necessary for place and response learning. We addressed these questions using administration of the muscarinic receptor antagonist, scopolamine, on both place and response learning in a food-rewarded T-maze task. the administration of scopolamine (15 mu g or 30 mu g) directly into the dorsal hippocampus impaired the performance of rats subjected to both place and cue-rich response version of the task, but did not affect the response version, when the task was performed under cue-poor conditions. However, the administration of scopolamine in the dorsolateral striatum impaired the cue-poor response version of the T-maze task without interfering with the place version or cue-rich response version. Taken together, these results indicate that activation of muscarinic cholinergic receptors in the hippocampus and striatum facilitate the use of different strategies of learning, thus strengthening the hypothesis of multiple memory systems. Additionally, these results emphasize the importance of the environmental conditions under which tasks are performed. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Fed Abc, Ctr Matemat Computacao & Cognicao, Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent320-326
dc.identifierhttp://dx.doi.org/10.1016/j.neuropharm.2013.06.009
dc.identifier.citationNeuropharmacology. Oxford: Pergamon-Elsevier B.V., v. 73, p. 320-326, 2013.
dc.identifier.doi10.1016/j.neuropharm.2013.06.009
dc.identifier.issn0028-3908
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36832
dc.identifier.wosWOS:000325233300031
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuropharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectScopolamineen
dc.subjectMuscarinic receptorsen
dc.subjectHippocampusen
dc.subjectStriatumen
dc.subjectPlace learningen
dc.subjectResponse learningen
dc.subjectMazeen
dc.titleInactivation of muscarinic receptors impairs place and response learning: Implications for multiple memory systemsen
dc.typeinfo:eu-repo/semantics/article
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