Elevation of soluble interleukin-2 receptor levels in the bronchoalveolar lavage from patients with systemic sclerosis

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dc.contributor.authorMartinez, JAB
dc.contributor.authorNishimura, C.
dc.contributor.authorGuatura, S. B.
dc.contributor.authorSato, E.
dc.contributor.authorKing, T. E.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNatl Jewish Med & Res Ctr
dc.contributor.institutionSan Francisco Gen Hosp
dc.contributor.institutionUniv Calif San Francisco
dc.date.accessioned2016-01-24T12:31:31Z
dc.date.available2016-01-24T12:31:31Z
dc.date.issued2001-11-01
dc.description.abstractThis study was designed to investigate the levels of IL-2 and its soluble receptor (sIL-2R) in bronchoalveolar lavage fluid (BALF) from patients with systemic sclerosis (SSc). We studied 18 patients with SSc and 10 healthy volunteers. Based on high-resolution computed tomography lung scans the patients were divided into two groups, those with (SSc-ILD group, n=10) and those without (SSc group, n=8) evidence of interstitial lung disease (ILD). Both groups showed significantly higher total cell and neutrophil counts in the BALF than controls. the SSc group also showed significantly higher levels of lymphocytes than controls. IL-2 was not detectable in BALF. the patients showed significantly higher levels of sIL-2R than controls (77.8% vs 20%, P=0.005). the median sIL-2R levels detected did not differ between the two patient groups (SSc-ILD 270 pg/ml, SSc 232 pg/ml). This study suggests that SSc patients with or without ILD have elevated levels of sIL-2R in BALF and that in some of these patients this finding could be explained by subclinical pulmonary inflammation.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Med, São Paulo, Brazil
dc.description.affiliationMed Sch Ribeirao Preto, Dept Internal Med, BR-14048900 Ribeirao Preto, SP, Brazil
dc.description.affiliationNatl Jewish Med & Res Ctr, Dept Med, Denver, CO USA
dc.description.affiliationSan Francisco Gen Hosp, Dept Med, San Francisco, CA 94110 USA
dc.description.affiliationUniv Calif San Francisco, San Francisco, CA 94143 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent122-126
dc.identifierhttp://dx.doi.org/10.1007/s00296-001-0147-x
dc.identifier.citationRheumatology International. New York: Springer-verlag, v. 21, n. 3, p. 122-126, 2001.
dc.identifier.doi10.1007/s00296-001-0147-x
dc.identifier.issn0172-8172
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26653
dc.identifier.wosWOS:000172676300008
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofRheumatology International
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectsoluble interleukin-2 receptoren
dc.subjectbronchoalveolar lavageen
dc.subjectsystemic sclerosisen
dc.subjectinterstitial lung diseaseen
dc.titleElevation of soluble interleukin-2 receptor levels in the bronchoalveolar lavage from patients with systemic sclerosisen
dc.typeinfo:eu-repo/semantics/article
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