The effect of menopause on objective sleep parameters: Data from an epidemiologic study in São Paulo, Brazil

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dc.contributor.authorHachul, Helena [UNIFESP]
dc.contributor.authorFrange, Cristina [UNIFESP]
dc.contributor.authorBezerra, Andreia Gomes [UNIFESP]
dc.contributor.authorHirotsu, Camila [UNIFESP]
dc.contributor.authorPires, Gabriel Natan [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorBittencourt, Lia [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCasa Saude Santa Marcelina
dc.date.accessioned2016-01-24T14:39:56Z
dc.date.available2016-01-24T14:39:56Z
dc.date.issued2015-02-01
dc.description.abstractObjective: Our objective was to investigate the influence of menopausal status on sleep patterns in a representative sample of women from São Paulo, Brazil.Study design: A population-based survey with a probabilistic three-stage cluster sample of the city of São Paulo was used to represent the local population according to gender, age (20-80 years) and socioeconomic status.Main outcome measures: the female participants answered a sleep questionnaire, underwent polysomnographic recording and allowed their hormone levels to be measured. They also completed a gynecological questionnaire for classification of the reproductive aging stages: premenopausal or reproductive, perimenopausal or menopausal transition, and postmenopausal, defined as being after 12 months of amenorrhea. Women were allocated into early (the first 5 years after menopause) and late (after the first 5 years) stages.Results: A total of 535 women were included in this study: 339 were premenopausal, 53 were early postmenopausal, 118 were late postmenopausal and 25 were using hormone therapy or isoflavone compounds. Our main findings were that women in postmenopause spent more time in N3 sleep, had a higher apnea-hypopnea index (AHI) and lower Sa02 compared with premenopausal women after an analysis adjusted for confounding factors. We found no significant differences between early and late postmenopausal women-in the adjusted analysis.Conclusion: Our results indicate menopause itself exerts a modest, but important influence on objective sleep patterns, independent of age, in particular on AHI and Sa02. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ginecol, BR-04024002 São Paulo, Brazil
dc.description.affiliationCasa Saude Santa Marcelina, Dept Ginecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ginecol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2014/15259-2
dc.description.sponsorshipIDCNPq: 300674/2013-9
dc.format.extent170-178
dc.identifierhttp://dx.doi.org/10.1016/j.maturitas.2014.11.002
dc.identifier.citationMaturitas. Clare: Elsevier B.V., v. 80, n. 2, p. 170-178, 2015.
dc.identifier.doi10.1016/j.maturitas.2014.11.002
dc.identifier.issn0378-5122
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38651
dc.identifier.wosWOS:000349271200010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMaturitas
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleepen
dc.subjectPolysomnographyen
dc.subjectPremenopausalen
dc.subjectPostmenopausalen
dc.subjectPopulation sampleen
dc.subjectWomenen
dc.titleThe effect of menopause on objective sleep parameters: Data from an epidemiologic study in São Paulo, Brazilen
dc.typeinfo:eu-repo/semantics/article
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