Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study

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dc.contributor.authorAndreatini, R.
dc.contributor.authorSartori, V. A.
dc.contributor.authorSeabra, MLV
dc.contributor.authorLeite, JR
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:34Z
dc.date.available2016-01-24T12:33:34Z
dc.date.issued2002-11-01
dc.description.abstractThe aim of the present study was to carry out a controlled pilot study on the putative anxiolytic effect of valepotriates. Thirty-six outpatients with generalized anxiety disorder (DSM III-R), after a 2-week washout, were randomized to one of the following three treatments for 4 weeks (n = 12 per group): valepot-riates (mean daily dose: 81.3 mg), diazepam (mean daily dose: 6.5 mg), or placebo. A parallel, double-blind, flexible-dose, placebo-controlled design was employed. No significant difference was observed among the three groups at baseline or in the change from baseline on the Hamilton anxiety scale (HAM-A) or in the trait part of the state-trait anxiety inventory (STAI-trait). Moreover, the three groups presented a significant reduction in the total HAM-A scores. On the other hand, only the diazepam and valepotriates groups showed a significant reduction in the psychic factor of HAM-A. the diazepam group also presented a significant reduction of the STAI-trait. Although the principal analysis (HAM-A between group comparison) found negative results (probably due to the small sample size in each group), the preliminary data obtained in the present study suggest that the valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety. However, since the number of subjects per group was very small, the present results must be viewed as preliminary. Thus, further studies addressing this issue are warranted. Copyright (C) 2002 John Wiley Sons, Ltd.en
dc.description.affiliationUniv Fed Parana, Dept Farmacol, Lab Fisiol & Farmacol Sistema Nemoso Cent, BR-81540970 Curitiba, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent650-654
dc.identifierhttp://dx.doi.org/10.1002/ptr.1027
dc.identifier.citationPhytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 16, n. 7, p. 650-654, 2002.
dc.identifier.doi10.1002/ptr.1027
dc.identifier.issn0951-418X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27016
dc.identifier.wosWOS:000179225800008
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofPhytotherapy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectcontrolled clinical trialen
dc.subjectdiazepamen
dc.subjectplaceboen
dc.subjectphytotherapyen
dc.subjectValeriana officinalisen
dc.titleEffect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot studyen
dc.typeinfo:eu-repo/semantics/article
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