Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats

Página do item simplificado
dc.contributor.authorAraujo, Leandro Pires [UNIFESP]
dc.contributor.authorTruzzi, Renata Ramos
dc.contributor.authorFlorido Mendes, Gloria Elisa
dc.contributor.authorMendes Luz, Marcus Alexandre
dc.contributor.authorBurdmann, Emmanuel A.
dc.contributor.authorOliani, Sonia Maria [UNIFESP]
dc.contributor.institutionSão Paulo State Univ UNESP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSao Jose do Rio Preto Med Sch
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:26:52Z
dc.date.available2016-01-24T14:26:52Z
dc.date.issued2012-03-01
dc.description.abstractCyclosporine (CsA) remains an important immunosuppressant for transplantation and for treatment of autoimmune diseases. the most troublesome side effect of CsA is renal injury. Acute CsA-induced nephrotoxicity is characterized by reduced renal blood flow (RBF) and glomerular filtration rate (GFR) due to afferent arteriole vasoconstriction. Annexin A1 (ANXA1) is a potent anti-inflammatory protein with protective effect in renal ischemia/reperfusion injury. Here we study the effects of ANXA1 treatment in an experimental model of acute CsA nephrotoxicity.Salt-depleted rats were randomized to treatment with VH (vehicles 1 mL/kg body weight/day), ANXA1 (Ac2-26 peptide 1 mg/kg body weight/day intraperitoneally), CsA (20 mg/kg body weight/day subcutaneously) and CsA + ANXA1 (combination) for seven days. We compared renal function and hemodynamics, renal histopathology, renal tissue macrophage infiltration and renal ANXA1 expression between the four groups.CsA significantly impaired GFR and RBF, caused tubular dilation and macrophage infiltration and increased ANXA1 renal tissue expression. Treatment with ANXA1 attenuated CSA-induced hemodynamic changes, tubular injury and macrophage infiltration.ANXA1 treatment attenuated renal hemodynamic injury and inflammation in an acute CsA nephrotoxicity model.en
dc.description.affiliationSão Paulo State Univ UNESP, Inst Biociencias Letras & Ciencias Exatas IBILCE, Dept Biol, BR-15054000 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Postgrad Program Morphol, São Paulo, Brazil
dc.description.affiliationSao Jose do Rio Preto Med Sch, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Postgrad Program Morphol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2008/01,048-9
dc.description.sponsorshipIDCNPq: 306,074/2007-9
dc.description.sponsorshipIDCNPq: 307,371/2006-9
dc.format.extent189-196
dc.identifierhttp://dx.doi.org/10.1007/s00011-011-0400-z
dc.identifier.citationInflammation Research. Basel: Springer Basel Ag, v. 61, n. 3, p. 189-196, 2012.
dc.identifier.doi10.1007/s00011-011-0400-z
dc.identifier.issn1023-3830
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34657
dc.identifier.wosWOS:000300292100002
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofInflammation Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectAcute renal injuryen
dc.subjectAnnexin A1en
dc.subjectCyclosporine nephrotoxicityen
dc.subjectImmunosuppressionen
dc.subjectInflammationen
dc.titleAnnexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in ratsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral